Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...
Patent
1977-07-28
1979-12-18
Naff, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an organic...
2601125R, 2601127, 424 78, 424 94, 424177, 424178, 435180, C07G 700, C07G 702, A61K 3726, A61K 3748
Patent
active
041793374
ABSTRACT:
Polypeptides such as enzymes and insulin are coupled to polyethylene glycol or polypropropylene glycol having a molecular weight of 500 to 20,000 daltons to provide a physiologically active non-immunogenic water soluble polypeptide composition. The polyethylene glycol or polypropylene glycol protect the polypeptide from loss of activity and the composition can be injected into the mammalian circulatory system with substantially no immunogenic response.
REFERENCES:
patent: 3607653 (1971-09-01), Ziffer et al.
patent: 3619371 (1971-11-01), Crook et al.
patent: 3639213 (1972-02-01), Ginger et al.
patent: 3645852 (1972-02-01), Axon et al.
patent: 3788948 (1974-01-01), Kagedal et al.
patent: 3959080 (1976-05-01), Orth et al.
patent: 4002531 (1977-01-01), Royer
patent: 4055635 (1977-10-01), Green et al.
Davis Frank F.
Palczuk Nicholas C.
Van Es Theodorus
Behr Omri M.
Naff David M.
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