Non-immunogenic, biocompatible macromolecular membrane compositi

Details Non-immunogenic, biocompatible macromolecular membrane compositi Non-immunogenic, biocompatible macromolecular membrane compositi

1995-04-05

1998-09-15

Fonda, Kathleen K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 54, 536 551, 536 553, 536 56, 5361231, 536124, 514 54, 514 57, 424443, 424488, C08B 3700, A61K 31715

Patent

active

058080503

ABSTRACT:
Non-immunogenic biocompatible macromolecular sheet composition are formed from a cellulosic membrane, a binding moiety having a plurality of functional groups, and a glycosaminoglycan (GAG). The binding moiety has the formula of R.sup.1 --X--R.sup.2 wherein R.sup.1 and R.sup.2 are the same or different. The binding moiety, through functional groups binds the cellulosic membrane with the glycosaminoglycan. R.sup.1 is covalently bound to a carbon or an oxygen of the cellulosic membrane. R.sup.2 is covalently bound to a carbon, an oxygen, or a nitrogen of the glycosaminoglycan. The binding moiety can be bis-oxyrane, butanediol-diglycidyl ether (BDE), or divinyl sulfone. The cellulosic membrane can be a cellulosic membrane, partially acetylated cellulose and a copolymer of hydroxyethyl-methacrylate with methyl methacrylate, abbreviated as HEMA-MMA. The non-immunogenic biocompatible macromolecular sheet composition can be formed into a pouch to encapsulate cells, tissues, pharmaceuticals, or biological metabolic products. In addition, the non-immunogenic biocompatible macromolecular sheet composition can also be used as a skin graft or a skin substitute. Further, these non-immunogenic biocompatible macromolecular sheet composition can also be used as a surface to culture cells in vitro.

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