Non-human transgenic mammals expressing an n-3 desaturase gene

Details Non-human transgenic mammals expressing an n-3 desaturase gene Non-human transgenic mammals expressing an n-3 desaturase gene

2007-07-03

2007-07-03

Crouch, Deborah (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S014000, C800S015000, C800S016000, C800S017000, C800S018000

Reexamination Certificate

active

10468318

ABSTRACT:
The present invention features compositions (e.g, nucleic acids encoding fat-1, optionally and operably linked to a constitutively active or tissue-specific promoter or other regulatory sequence and pharmaceutically acceptable formulations including that nucleic acid or biologically active variants thereof) and methods that can be used to effectively modify the content of PUFAs in animal cells (i.e., cells other than those ofC. elegants, for example, mammalian cells such as myocytes, neurons (whether of the periferal or central nervous system), adipocytes, endothelial cells, and cancer cells). The modified cells, whether in vivo or ex vivo (e.g., in tissue culture), transgenic animals containing them, and food products obtained from those animals (e.g., meat or other edible parts of the animals (e.g., liver, kidney, or sweetbreads)) are also within the scope of the present invention.

REFERENCES:
patent: 2003/0196217 (2003-10-01), Mukerji et al.
Spychalla PNAS, USA, 94: 1142-1147 (Feb. 1997).
Strunk et al. (2004) Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned. Gentics 167:1821-1832.
Sanford et al. (2001) Influence of Genetic Background on knockout mouse phenotypes. Methods Mol. Biol. 158:217-225.
Cameron et al. (1997) Recent Advances in Transgenic Technology. Molecular Biotechnology. 7:253-265.
Wall et al. (1996) Transgenic Livestock: Progress and prospects for the future. Theriogenology 45:57-68.
Houdebine et al. (1994) Production of pharmaceutical proteins from transgenic animals. Journal of Biotechnology. 34:269-287.
Sequence alignment (Mar. 29, 2005) pp. 1-7.
Sigmund, C., Jun. 2000, Arterioscler. Thromb. Vasc. Biol., p. 1425-1429.
Houdebine, L-M., 2002, Journal of Biotechnology, vol. 98, p. 145-160.
Kolb et al. (1999) Insertion of a foriegn gene into the beta-casein locus by Cre-mediated site-specific recombination. Gene 227:21-31.
Houdebine. (2000) Transgenic animal bioreactors. Transgenic Research. 9:305-320.
Murray et al. (1999) Genetic modification of animals in the next century. Theriogenoogy. 51:149-159.
Albert et al.,JAMA279:23-28 (1998).
Agren et al.,Prostagland. Leukot. Essent. Fatty Acids57:419-421 (1997).
AHA Dietary Guidelines: Revision 2000, Circulation 102:2284-2299 (2000).
Appel et al.,Arch. Intern. Med. 153:1429-1438 (1993).
Ariza-Ariza et al.,Semin. Arthritis Rheum. 27:366-370 (1998).
Arondel et al.,Science258:1353-1355 (1992).
Belluzzi et al.,N. Engl. J. Med. 334:1557-1560 (1996).
Bezzi et al.,Nature391:281-285 (1998).
Bougnoux,Curr. Opin. Clin. Nutr. Metab. Care2:121-126 (1999).
Broun et al.,Annu. Rev. Nutr. 19:197-216 (1999).
Browse and Somerville,Annu. Rev. Plant Physiol. Plant Mol. Biol. 42:467-506 (1991).
Calder,Ann. Nutr. Metab. 41:203-234 (1997).
Carrie et al.,Neurosci. Lett. 266:69-72 (1999).
Cave,Breast Cancer Res. Treat. 46:239-246 (1997).
Clandinin et al.,Can. J. Physiol. Pharmacol. 63:546-556 (1985).
Clarke,Br. J. Nutr. 83:S59-S66 (2000).
Connor,Am. J. Clin. Nutr. 70:951-952 (1999).
Diaz et al.,J. Virol. 72:789-795 (1998).
De Caterina et al.,Kidney Int. 44:843-850 (1993).
DeLorgeril et al.,Circulation99:779-785 (1999).
Drachman and Rothstein,Ann Neurol. 48:792-795 (2000).
Dyerberg and Bang,Lancet2:433-435 (1979).
Dyerberg et al.,Lancet2:117-119 (1978).
Gill and Valivety,Trends Biotechnol. 15:401-409 (1997).
GISSI-Prevenzione Investigators,Lancet354:447-455 (1999).
Goodnight et al.,Blood58:880-885 (1981).
Guallar et al.,Arterioscler. Thromb. Vasc. Biol. 19:1111-1118 (1999).
Hajjar et al.,Circulation95:423-429 (1997).
Hajjar et al.,Circ. Res. 81:145-153 (1997).
Hajjar et al.,Proc. Natl. Acad. Sci. USA95:5251-5256 (1998).
Harris,Am. J. Clin. Nutr. 65:1645S-1654S (1997).
He et al.,Proc. Natl. Acad. Sci. USA95:2509-2514 (1998).
Ho et al.,Cancer Res. 53:641-651 (1993).
Hoffman and Birch,World Rev. Nutr. Diet83:52-60 (1998).
Hu et al.,Cancer Res. 57(16):3339-3343 (1997).
Hu et al.,Am. J. Clin. Nutr. 69:890-897 (1999).
James et al.,Am. J. Clin Nutr. 71:343S-348S (2000).
Kang and Leaf,Circulation94:1774-1780 (1996).
Kang et al.,Biochim. Biophys. Acta1128:267-274 (1992).
Kang et al.,Proc. Natl. Acad. Sci. USA98:4050-4054 (2001).
Kaneko et al.,Cancer Res. 55:5283-5287 (1995).
Knutzon et al.,J. Biol. Chem. 273:29360-29366 (1998).
Kremer,Am. J. Clin. Nutr. 71:349S-351S (2000).
Leaf and Kang,World Rev. Nutr. Diet. 83:24-37 (1998).
Leaf and Weber,Am. J. Clin. Nutr. 45:1048-1053 (1987).
Mahendroo et al.,J. Biol. Chem. 268:19463-19470 (1993).
McLennan et al.,Am. Heart J. 116:709-717 (1988).
Miyatake et al.,J. Virol. 71:5124-5132 (1997).
Mori et al.,Arterioscler. Throm. Vasc. Biol. 17:279-286 (1997).
Napier et al.,Curr. Opin. Plant Biol. 2:123-127 (1999).
Needleman et al.,Ann. Rev. Biochem. 55:69-102 (1986).
Neuringer et al.,Proc. Natl. Acad. Sci USA83:4021-4025 (1986).
Niwa et al.,Gene108:193-200 (1991).
Okabe et al.,FEBS Lett. 407:313-319 (1997).
O'Keefe and Harris,Mayo Clin. Proc. 75:607-614 (2000).
Okuley et al.,Plant Cell6:147-158 (1994).
Otto et al.,Transplantation50:193-198 (1990).
Ozaki et al.,Hum Gene Ther. 7:1483-1490 (1996).
Price et al.,Curr. Opin. Lipidol. 11:3-7 (2000).
Raheja et al.,Ann. N.Y. Acad. Sci. 683:258-271 (1993).
Reddy et al.,Trends Neurosc. 22:248-255 (1999).
Rose and Connolly,Pharmacol. Ther. 83:217-244 (1999).
Ruther et al.,EMBO J., 2:1794 (1983).
Salem et al.,Lipids31:S1-S326 (1996).
Sanzgiri et al.,J. Neurobiol. 41:221-229 (1999).
Schousboe et al., In a Dissection and Tissue Culture Manual of the Nervous System, Shahar et al., Eds., Alan R. Liss, New York, N.Y., pp. 203-206 (1989).
Sellmayer et al.,Lipids31:S37-S40 (1996).
Shahar et al.,N. Engl. J. Med. 331:228-233 (1994).
Shi et al.,Hum Gene Ther. 8:403-410 (1997).
Simpson et al.,Clin. Chem. 39:317-324 (1993).
Simopoulos,Am. J. Clin. Nutr. 70:560S-569S (1999).
Simopoulos,Food Australia51:332-333 (1999).
Simopoulos,Poultry Science79:961-970 (2000).
Singh et al.,Cardiovasc. Drugs Ther. 11:485-491 (1997).
Siscovick et al.,JAMA274:1363-1367 (1995).
Smith and Borgeat, In Biochemistry of Lipids and Membranes, D.E. Vance, Eds., Benjamin/Cummings, Menlo Park, CA, 00 325-360 (1985).
Smith and Johnson,Gene67:31-40 (1988).
Spychalla et al.,Proc. Natl. Acad. Sci. USA94:1142-1147 (1997).
Stenson et al.,Ann. Intern. Med. 116:609-614 (1992).
Suzuki et al.,Hum Gene Ther. 7:1883-1893 (1996).
Uauy et al.,Proc. Nutr. Soc. 59:3-15 (2000).
Uauy et al.,Lipids36:885-895 (2001).
Vancassel et al.,Prost. Leuk. Ess. Fatt. Acids65:1-7 (2001).
Von Schacky et al.,Ann. Intern. Med. 130:554-562 (1999).
Von Schacky,J. Lab. Clin. Med. 128:5-6 (1996).
Wada et al.,Nucleic Acids Res. 20:2111-2118 (1992).
Weylandt et al.,Lipids31:977-982 (1996).
Ziboh,World Rev. Nutr. Diet66:425-435 (1991).
Kelder et al. “Expression of fungal desaturase in cultured mammalian cells.” Molecular and Cellular Biochemistry 219: 7-11 (2001).
Yadav et al. “Cloning of Higher Plant w-3 Fatty Acid Desaturases.” Plant Physiol. 103: 467-476 (1993).
Sakamoto et al. “Cloning of w3 desaturase from cyanobacteria and its use in altering the degree of membrane-lipid unsaturation.” Plant Molecular Biology 26: 249-263 (1994).

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