Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2007-09-04
2007-09-04
Falk, Anne-Marie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
Reexamination Certificate
active
10493967
ABSTRACT:
The present invention is to provide a non-human animal model of systemic lupus erythematosus wherein generation of anti-double stranded DNA antibody and anti-single stranded antibody is induced, and that is made to spontaneously develop glomerulonephritis and arthritis, and a screening method for a therapeutic agent for systemic lupus erythematosus wherein the non-human animal model is used. FcγRIIB deficient mouse that is not made to spontaneously develop autoimmune pathology although its autoantibody response is enhanced is backcrossed into C57BL/6J (B6) mouse for 12 generations to generate FcγRIIB deficient B6 mouse, the FcγRIIB deficient B6 male mouse is intercrossed with lpr/B6 female mouse, and thus obtained FcγRIIB+/−/lpr+/−mice were further crossed to generate a mouse model of systemic lupus erythematosus.
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Nakamura Akira
Takai Toshiyuki
Yajima Kaori
Falk Anne-Marie
Foley and Lardner LLP
Japan Science and Technology Agency
Noble Marcia S.
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