Non-human animal model of a human airway, methods of use

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition

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424557, 435 11, A61K 4900, A61K 3542, A01N 102, C12N 500

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056677669

ABSTRACT:
A non-human animal characterized by a human airway, the human airway being open-ended. The human airway is characterized by cells derived from the human respiratory system. The non-human animal and the human airway it carries are useful as models of human airways, particularly diseased human airways, for example, human CF airways. They are also useful to predict the efficacy or toxicity of agents and therapies on human airways, particularly on diseased human airways, for example, human CF airways.

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