Non-human animal exhibiting bone metastasis of tumor cells

Details Non-human animal exhibiting bone metastasis of tumor cells Non-human animal exhibiting bone metastasis of tumor cells

2008-07-22

2008-07-22

Li, Q. Janice (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

The nonhuman animal is a model for human disease

C800S008000, C800S009000, C424S009200

Reexamination Certificate

active

11120508

ABSTRACT:
The present invention provides a non-human bone metastasis model animal in which tumor cells capable of inducing bone metastasis by peripheral administration have been introduced, and a method for producing the animal.The bone metastasis model animal in the present invention may be useful for understanding the biology of bone metastasis and developing novel therapeutic strategies for lung cancer patient with multi-organ metastases, including bone metastasis.

REFERENCES:
patent: 5643551 (1997-07-01), Namikawa et al.
patent: 5928641 (1999-07-01), Seon
patent: 5993817 (1999-11-01), Yoneda et al.
patent: 6365797 (2002-04-01), Sawyers et al.
patent: 7135609 (2006-11-01), Sone
Arguello et al.,Cancer Res.48:6876-6881 (1988).
Blomme et al.,Prostate39:187-197 (1999).
Dougherty et al.,Cancer Res.59:6015-6022 (1999).
Engebraaten et al.,Int. J. Cancer82:219-225 (1999).
Faguet et al.,Blood71:1511-1517 (1988).
Faguet et al.,Blood71:422-429 (1988).
Fodstad et al.,J. Cell Biochem.56:23-28 (1994).
Gresser et al.,Int. J. Cancer63:726-731 (1995).
Guise et al.,J. Bone Min. Res.9:S128 (1994).
Hall et al.,J. Bone Miner. Res.9:221-230, (1994).
Hanibuchi et al.,Int. J. Cancer78:480-485 (1998).
Iguchi et al.Cancer Res.56:4040-4043 (1996).
Ishigaki et al.,Folia Microbiol.43:493-494 (1998).
Jamasbi et al.,Br. J. Cancer36:723-729 (1977).
Kaufman et al.,Annu Rev. Immunol.13:339-367 (1995).
Lelekakis et al.,Clin. Exp. Metastasis17:163-170 (1999).
Mehta et al.,Breast Cancer Res. and Treat.25:65-71 (1993).
Mickey et al.,Int. J. Immunopharmac.11:829-838 (1989).
Miki et al.,Oncol. Res.12:209-217 (2000).
Miki et al., 9th Meeting of the Japanese Association for Metastasis Research (JAMR), Third Department of Internal Medicine, University of Tokushima, Jun. 29-30, 2000, p. 55.
Mule et al.,J. Immunother.12:196-198 (1992).
Mundy et al.,Seminars in Oncology28(2) Suppl. 6:35-44 (2001).
Nakai et al.,Cancer Res.52:5395-5399 (1992).
Niederkorn et al.,Inv. Ophthal. Vis. Science27:1355-1361 (1986).
Rabbani et al.,Int. J. Cancer80:257-264 (1999).
Sasaki et al.,Cancer Res.55:3551-3557 (1995).
Shevrin et al.,Prostate19:149-154 (1991).
Turner et al.,J. Neuro-Oncol.8:121-132 (1990).
Yano et al.,Int. J. Cancer67:211-217 (1996).
Yoneda et al.,J. Bone Miner Res.16:1486-1495 (2001).
Office Action in U.S. Appl. No. 09/864,364, mailed on Jan. 16, 2002.
Response filed in U.S. Appl. No. 09/864,364, on Jul. 15, 2002.
Office Action in U.S. Appl. No. 09/864,364, mailed on Oct. 23, 2002.
Response filed in U.S. Appl. No. 09/864,364, on Mar. 21, 2003.
Office Action in U.S. Appl. No. 09/864,364, mailed on Jun. 3, 2003.
Response filed in U.S. Appl. No. 09/864,364, on Dec. 1, 2003.
Office Action in U.S. Appl. No. 09/864,364, mailed on Feb. 25, 2004.
Response filed in U.S. Appl. No. 09/864,364, on Aug. 11, 2004.
Office Action in U.S. Appl. No. 09/864,364, mailed on Nov. 2, 2004.
Office Action in U.S. Appl. No. 10/143,364, mailed on Oct. 6, 2004.
Response filed in U.S. Appl. No. 10/143,364, on Apr. 6, 2005.
Office Action in U.S. Appl. No. 10/143,364, mailed on Jun. 20, 2005.
Response filed in U.S. Appl. No. 10/143,364, on Dec. 19, 2005.
Notice of Allowance, Notice of Allowability, Examiner's Amendment, and Examiner-Initiated Interview Summary in U.S. Appl. No. 10/143,364, mailed on Feb. 2, 2006.
U.S. Appl. No. 11/439,603, as filed May 23, 2006.
Preliminary Amendment filed in U.S. Appl. No. 11/439,603 on May 23, 2006.

Affiliated with

Also associated with

Rating

Non-human animal exhibiting bone metastasis of tumor cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-human animal exhibiting bone metastasis of tumor cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-human animal exhibiting bone metastasis of tumor cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3926562