Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Reexamination Certificate
2005-12-27
2010-02-09
Saucier, Sandra (Department: 1651)
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
C435S118000, C435S135000
Reexamination Certificate
active
07659106
ABSTRACT:
The present invention relates to a process for the biocatalyst-mediated enantioselective conversion of enantiomeric mixtures of hydrophobic esters using a biphasic solvent system. More particularly, the present invention relates to the enzyme-mediated enantioselective synthesis of anti-viral compounds, such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (FTC) and its analogues, in a non-homogenous reaction system.
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Almond Merrick R.
Fong Wang Yi
Yiming Yao
Altus Pharmaceuticals Inc.
Gilead Sciences, Inc.
Hanley Susan
King & Spalding
Saucier Sandra
LandOfFree
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