Drug – bio-affecting and body treating compositions – Dentifrices – Ammonia – amine – or derivative thereof
Reexamination Certificate
2003-05-21
2004-08-03
Krass, Frederick (Department: 1614)
Drug, bio-affecting and body treating compositions
Dentifrices
Ammonia, amine, or derivative thereof
C514S556000, C514S900000, C514S902000, C514S944000
Reexamination Certificate
active
06770268
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to an improvement in periodontic compositions used in connection with tooth extractions and the treatment of gum diseases by dentists. More particularly, the present invention relates to a bleaching non-foaming gel antimicrobial periodontic composition, which contains a betaine compound and is free of alcohol, for use in the treatment of gum diseases, especially gingivitis and tooth whitening. Further, the compositions of the invention are incorporated in a mouth wash.
BACKGROUND OF THE INVENTION
It is desirable for uses in dentifices that a stable minimal or non-foaming gel be used in dentifices and in compositions used in treating gum diseases, it is advisable to provide a composition free of alcohols. Alcoholic compositions are considered as being potentially carcinogenic. The use of most gums or gels to improve the stability or foamability of the composition also dilutes the anti-microbial effect.
It is further desirable to provide a low foaming mouth wash having good detergency, tooth bleaching and high efficiency fragrance coupling.
A variety of microorganisms are also present in the oral cavity. These range from the natural flora of the host to pathogenic species. Among these microorganisms are the gram-positive rods associated with the formation of plaque (a dense, enamel adherent, microorganism-containing polysaccharide matrix). Even with good oral hygiene, it has been shown that microorganisms (including those responsible for plaque formation) rapidly build up in the oral cavity. Specific areas, including periodontal and subgingival spaces, and interpapillary spaces of the tongue present environments that harbor bateria. These species are difficult to reach by toothbrushing, and are only moderately affected by standard mouthwashes. The persistence of these microorganisms in such environments greatly increases, the risk of calculus and plaque build up and carie formation, which in turn presents the danger of gingival inflammation and periodontal disease.
Although mouthwashes are standard in oral hygiene, they have generally been used to mask halitosis. Several mouthwashes that have been marketed for the reduction of bacteria and the prevention of plaque buildup generally rely on a combination of alcohols (e.g. thymol, eucalyptol, ethanol; such as Listerine), a combination of alcohols and a quaternary amine (e.g. ethanol, cetylpyridinium chloride; such as Scope) or other oral surfactants (see U.S. Pat. No. 4,657,758), or of alcohol and chlorhexidine digluconate (Peridex from Proctor and Gamble). However, the use of alcohol containing formulations tends to produce unpleasant side effects including pain and stinging of the oral mucosa, foul aftertaste and discoloration of teeth. Prior art attempts to address this issue have included the use of a cetylpyridinium chloride in the presence of an oral surfactant (Lander Alcohol Free Mouthwash from the Lander Company, Inc.) and the use of stabilized chlorine (RetarDent from Rowpar). Because stabilized chlorine molecules are inactivated by interactions with proteins found in the mouth, they are unable to penetrate the occult, non-surface environments inhabited by microorganisms making these types of alcohol-free formulations of limited efficacy. In addition to this, these formulations sting open sores or cuts in the mouth.
U.S. Pat. No. 4,839,158 to Michaels, which is herein incorporated by reference discloses a dentifrice containing a betaine in an alcoholic composition containing gels, gums, and the like to form a foamable product. However, the addition of such foaming agents dilutes the anti-microbial effect of the composition and the foam produced is not stable for a sufficient length of time.
U.S. Pat. No. 5,389,676 to Michaels, which is herein incorporated by reference, discloses anti-infective water-in-oil or oil-in-water compositions comprising amphoteric surfactants of amine oxides, hydrophobic materials and emulsions aids, which can be used as a dentifrice. The compositions containing gelatins to improve Bloom strength and create a gel which results in a dilution of the antimicrobial effect.
U.S. Pat. Nos. 4,062,976, 4,127,328, 4,183,852, and 4,837,158 disclose amphoteric betaine and amine oxide foamable compositions but not those with a stable foam.
SUMMARY OF THE INVENTION
The present invention relates to an anti-infective, non-foaming periodontic gel compositions which is free from alcohols, which can be used in treating gum diseases, and whitening teeth. More particularly, there is provided a composition comprising an isoalkyl dimethyl amine oxide in combination with a betaine with a controlled foam which is free of clouding.
The composition contains about 0.1 to 10% mixture of the betaine and the isoalkyl dimethyl amine oxide in combination with optional fillers. Preferably, the composition comprises a ratio of about 1 to 2 betaine to an amine oxide compound of the formula:
wherein R is an aliphatic alkyl group of 7 to 14 carbon atoms.
Advantageously, the compositions of the invention can be incorporated into a dentifrice or a mouth wash.
It is therefore a general object of the invention to provide an anti-infective gel non-foaming periodontic composition having a broad spectrum of antimicrobial activity.
It is a further object of the invention to provide a non-foaming gel dentifrice which whitens teeth and is effective in treating gingivitis.
It is yet another object of the invention to provide a mouth wash composition to prevent staining of tooth enamel.
It is another object of the invention to provide a high detergency bleaching dentifrice and mouth wash.
It is a further object of the invention to treat a patient suffering from a gum disease with a dentifrice and/or a mouth wash.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
In accordance with the invention there is provided an anti-infective non-foaming periodontic composition in the form of a dentifrice or mouth wash.
More particularly, there is provided a periodontic composition comprising about 0.1 to 10.0 weight percent of a mixture of a betaine and an so alkyl dimethylamine oxide wherein the betaine compound is in a ratio to the ethyloxylated tertiary amine of 1:3 to 5:1, preferably about 1:2. The non-foaming characteristics of the composition provides longer antimicrobial activity and improved adherence to the gums and teeth.
The iso-alkyldimethyl amine oxides of the invention have the general formula:
wherein R is an alkyl group having 7 to 14 carbon atoms such as deca, undeca, dodeca, and trideca.
Suitable compounds include N,N-dimethy-1-(10-methyl-decanamine oxide), which is also known as 10 methyldecyl-N,N-dimethylamine oxide, N,N-dimethyl-1-(11-methyl-undecanamine oxide), N,N-dimethyl-1-(12-methyl-dodecanamine oxide), N,N-dimethyl-1-(13-methyl-tridecanamine oxide), N,N-dimethyl-1-(14-methyl-tetradecanamine-oxide).
Illustrative of the betaine are: (1) coco-N-betaine, stearyl-N-betaine, isostearyl-N-betaine, oleyl-N-sulfobetaine; and (3) cocoamido-N-betaine, cetylamido-N-betaine, stearylamido-N-betaine, isostearylamido-N-betaine, oleyl-amino-N-betaine, and the like.
When used here the term “coco” is that used in the CTFA (designations of Cosmetic and Toiletry and Fragrance Association, Wash. D.C.) and is used to indicate alkyl groups present in coconut oil, i.e. a mixture of alkyl groups from 10 to 18 carbon atoms. The designations of the compounds listed herein are those of the CTFA.
Preferably, the betaines used in this invention are selected from the group consisting of (a) alkyl N-sulfobetaines, acyl-N-betaines, and mistures of two or more thereof. The term betaine when used herein means N-dimethyl glycine and its lower alkyl homologs. Unless otherwise specified an N-dimethyl compound is intended. The term sulfobetaine or sultaine means the sulfuric acid analog of such betaines.
Typically, the betaine and amine oxide components are present in molar ratios of from 1:3 to 5:1, preferably in a molar ratio of about 1:2. In general the acid necessary, when necessary to supply the required pH to the am
Hall Dave
Hunt James R.
Krass Frederick
Lezdey John
Oratec Corp.
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