Non-fluorescent energy transfer

Details Non-fluorescent energy transfer Non-fluorescent energy transfer

2006-10-05

2010-06-22

Horlick, Kenneth R. (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

Reexamination Certificate

active

07741467

ABSTRACT:
The present invention relates generally to the transfer of non-fluorescent energy between donor and acceptor moieties. In certain embodiments, the invention provides biomolecules that include substantially non-fluorescent donor moieties. Processes involving these donor moieties typically entail reduced background fluorescence relative to applications that involve conventional fluorescent donor moieties. In addition to reaction mixtures and methods that include the use of these biomolecules, the invention also provides related kits and systems.

REFERENCES:
patent: 4318846 (1982-03-01), Khanna et al.
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 5188934 (1993-02-01), Menchen et al.
patent: 5366860 (1994-11-01), Bergot et al.
patent: 5434088 (1995-07-01), Ikeda et al.
patent: 5565322 (1996-10-01), Heller
patent: 5688648 (1997-11-01), Mathies et al.
patent: 5800996 (1998-09-01), Lee et al.
patent: 5863727 (1999-01-01), Lee et al.
patent: 5928907 (1999-07-01), Woudneberg et al.
patent: 5945526 (1999-08-01), Lee et al.
patent: 6114518 (2000-09-01), Pitner et al.
patent: 6117635 (2000-09-01), Nazarenko et al.
patent: 6214979 (2001-04-01), Gelfand et al.
patent: 6335440 (2002-01-01), Lee et al.
patent: 6573054 (2003-06-01), Patel et al.
patent: 6610842 (2003-08-01), Ravikumar et al.
patent: 6734297 (2004-05-01), Kempe
patent: 6768000 (2004-07-01), Nardone et al.
patent: 6821727 (2004-11-01), Livak et al.
patent: 2003/0143594 (2003-07-01), Mathies et al.
patent: 2003/0175785 (2003-09-01), Patel et al.
patent: 2004/0197793 (2004-10-01), Hassibi et al.
patent: 2005/0164316 (2005-07-01), Bray
patent: 2005/0287548 (2005-12-01), Bao et al.
patent: 0 050 684 (1980-10-01), None
patent: 0 144 914 (1984-11-01), None
patent: 0 476 545 (1991-09-01), None
patent: 1 067 134 (2001-01-01), None
patent: WO 93/09128 (1993-05-01), None
patent: WO 01/14612 (1998-04-01), None
patent: WO 00/06778 (2000-02-01), None
patent: WO 01/86001 (2001-11-01), None
patent: WO 03/002975 (2003-01-01), None
patent: WO 03/043402 (2003-05-01), None
patent: WO 2005/030979 (2005-04-01), None
patent: EP2006/009646 (2007-01-01), None
patent: EP2006/009646 (2007-04-01), None
Afonina, I., et al, 2002, “Single Nucleotide Polymorphism Detection with MGB Eclipse™ Assays”,Journal of Clinical Ligand Assay, 25 (3): 268-275.
Bonnet, G., et al, 1999, “Thermodynamic basis of the enhanced specificity of structured DNA probes”,Proc. Natl. Acad. Sci. USA, 96: 6171-6176.
Gullberg, M., et al, 2004, “Cytokine detection by antibody-based proximity ligation”,Proceedings of the National Academy of Sciences of the USA, 101(22): 8420-8424.
Ju, J., et al, 1995, “Fluorescence energy transfer dye-labeled primers for DNA sequencing and anaylysis”,Proc. Natl. Acad. Sci USA, 92 4347-4351.
Khanna, P., et al, 1980, “4',5'-Dimethoxy-6-carboxyfluorescein: A Novel Dipole-Dipole Coupled Fluorescence Energy Transfer Acceptor Useful for Fluorescence Immunoassays”,Analytical Biochemistry, 108: 156-161.
Lukhtanov, E., et al, 2001, “Fluorogenic Dna probes for multicolor hybridization assays”,American Biotechnology Laboratory, 68-69.
Olejnik, J., et al, 1996, “Photocleavable biotin phosphoramidite for 5'-end-labeling, affinity purification and phosphorylation of synthetic oligonucleotides”,Nucleic Acids Research, 24 (2): 631-366.
Pon, R., et al, 2004, “Linker phosphoramidite reagents for the attachment of the first nucleoside to underivatized solid-phase supports”,Nucleic Acids Research, 32 (2): 623-631.
Phycolink, 1999, “Can Phycobiliproteins be used in Fluorescent Resonance Energy Transfer (FRET)?”, www.prozyme.com/faqs/pjfretfaq.html, 1-6.
Sabbagh, G., et al, 2004, “Synthesis of phosphorothioamidites derived from 3'-thio-3'-deoxythymidine and 3'-thio-2',3'-dideoxycytidine and the automated synthesis of oligodeoxynucleotides containing a 3'- S-phosphorothiolate linkage”,Nucleic Acids Research, 32 (2): 495-501.
Sokol, D., et al, 1998, “Real time detection of DNA-RNA hybridization in living cells”,Proc. Natl. Acad. Sci. USA, 95 11538-11543.
Song, X, et al., 2001, “Detection of Multivalent Interactions through Two-Tiered Energy Transfer”,Analytical Biochemistry, 291: 133-141.
Stevens, S., et al, 2002, “Comparison of Quantitative competitive PCR with Light Cycler-Based PCR for Measuring Epstein-Barr Virus DNA Load in Clinical Specimens”,Journal of Clinical Microbiology, 40(11): 3986-3992.
Tsuji, A., et al, “Development of a Time-Resolved Fluorometric method for Observing Hybridization in Living Cells Using Fluorescence Resonance Energy Transfer”,Biophysical Journal, 81: 501-515, 2001.

Affiliated with

Also associated with

Rating

Non-fluorescent energy transfer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-fluorescent energy transfer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-fluorescent energy transfer will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4234134