Non-fibrous porous material, wound dressing and method of making

Details Non-fibrous porous material, wound dressing and method of making Non-fibrous porous material, wound dressing and method of making

1996-03-29

1998-04-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Wearing apparel, fabric, or cloth

424404, 424444, 424445, A01N 2534, A61L 1516

Patent

active

057388601

DESCRIPTION:

BRIEF SUMMARY
BACKGROUND OF THE INVENTION

This application is a 302SC371 of PCT DK 94/00312 filed Aug. 19, 1994.
The present invention concerns a non-fibrous porous material essentially consisting of one or more hydrophilic polymers and/or pharmaceutical water-soluble medicaments, a method of making such a material, and a wound dressing comprising such a material.
A large number of porous materials of the above-mentioned type are known today. Such materials find widespread use in the sick-care technology and are used e.g. in products for surgical or dental application, in haemophase-active products and implants. Such materials are moreover extensively used for the treatment of wounds.
Known products for haemophase include e.g. Suricet (Johnson & Johnson) based on oxidized regenerated cellulose, Collastat (Kendall) based on collagen, Thrombostat (Warner Lambert) based on prothrombin, and Spongostan (Ferrosan) based on gelatine.
Known products for wound treatment include in particular Sorbsan (Steriseal) based on calcium alginate, and Kaltostar (Brit Cair) based on sodium and calcium alginate.
In products of the type mentioned above, the structure of the material is of very great importance. Particularly, it has been found that the structure of the material is of great importance for its ability to rehydrate or absorb liquid, such as wound exudate and other exuding body fluids.
The object of the present invention is to provide a novel material of the type stated in the opening paragraph which has particularly good rehydration and/or absorption properties, and which therefore lends itself extremely well for use in or as wound treatment products, such as dressings.
As mentioned above, it is generally known to use porous hydrophilic polymer materials in wound dressings.
A wound dressing comprising such a porous hydrophilic polymer material is mentioned e.g. in SE published application No. 453 566. The dressing described in this document consists of an adhesive liquid permeable layer, a layer of a liquid impermeable film, and a layer of a porous hydrophilic polymer material with open pores interposed between said two layers.
DK patent application No. 1487/90 moreover describes a porous material for use in the treatment of wounds. The material is prepared by freeze-drying of a gel consisting of a hydrocolloid and a wound-healing component, such as growth hormone, to provide a porous material having evenly distributed pores.
Porous hydrophilic polymer materials based on polysaccharides rides are generally used in wound dressings because of their good properties with respect to giving the wound optimum healing conditions. The surrounding environment of the wound-is thus of great importance to the healing rate.
One of the most important properties of polysaccharide-based materials is their liquid absorbing ability. Thus, such materials are frequently used in occlusive and semipermeable dressings, since they absorb the wound exudate without desiccating the wound. It is important that the wound, and in particular the skin surrounding the wound, is not too wet, since the skin will then macerate and involve the risk of liquid running under the dressing, which may establish a passage for dirt and bacteria into the wound.
The known polysaccharide-based materials are most frequently in the form of fibrous woven or non-woven materials. Such materials are mentioned e.g. in the WO patent applications Nos. 80/02300 and 89/12471, U.S. Pat. No. 3,824,997 and EP patent application No. 476 756. The materials disclosed in these are mainly based on a mixture of alginate salts. However, such fibres greatly tend to stick to the rim of the wound or to leave residues in the wound when removed due to their poor integrity, which is very inexpedient, because the fragile newly formed tissue is easily damaged. It moreover involves the risk of the fibres sticking to the newly formed wound tissue.
The patent literature also includes some non-fibrous polysaccharide-based porous materials, e.g. in the form of foamed gels which are formed in situ at the wound

REFERENCES:
patent: 4906488 (1990-03-01), Pera
patent: 4950454 (1990-08-01), Masuda et al.
patent: 5149469 (1992-09-01), Komatsuzaki et al.
patent: 5547848 (1996-08-01), Shinoki et al.

Affiliated with

Also associated with

Rating

Non-fibrous porous material, wound dressing and method of making does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-fibrous porous material, wound dressing and method of making, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-fibrous porous material, wound dressing and method of making will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-632723