Non-fibrogenic high mannuronate alginate coated transplants, pro

Details Non-fibrogenic high mannuronate alginate coated transplants, pro Non-fibrogenic high mannuronate alginate coated transplants, pro

1994-09-02

1997-12-02

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435177, 435182, 435325, 435382, 424424, C12N 1110, C12N 1112, C12N 1108

Patent

active

056935145

ABSTRACT:
A transplant with a core of a viable, physiologically active, cell(s) and a non-fibrogenic coating of alkaline earth metal alginate having a high mannuronate to guluronate molar ratio and free from fibrogenic amounts of fucose, sulfate, phloroglucinol and protein moieties. The coating has a permeability sufficiently low and a thickness sufficiently large to protect the tissue cells from host immunological agents after transplantation, the coating also being sufficiently permeable and thin to permit the diffusion of cell sufficient nutrients and cell products through the coating required for cell viability. The alginate coating can be reacted with polylysine to form a polylysine-alginate complex on the outer surface thereof. The complex can then be reacted with polyaspartic acid to provide a physiologically acceptable negative surface charge.

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