Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1992-05-29
1995-07-04
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424423, 264 41, 435 1, 435177, 435178, 435179, 435180, 435182, 43524022, 435240241, 435240243, 623 11, A61F 202, A01N 102, C12N 508
Patent
active
054298210
ABSTRACT:
A transplant comprising a core of a viable, physiologically active cells coated with a non-fibrogenic alkaline earth metal alginate free from fibrogenic amounts of fucose, sulfate, phloroglucinol and protein moieties, having a mannuronate to guluronate molar ratio of from 1.2 to 6. The coating protects the core from host immunological destruction after transplantation. The coating is sufficiently permeable to permit the diffusion of nutrients and cell products through the coating.
A process for coating the transplant core comprising coating the core with alginate substantially free from fibrogenic compounds and reacting the alginate coating with alkaline earth metal cations comprising calcium ions or magnesium ions or mixture thereof to form an alkaline earth metal alginate coating.
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Cochrum Kent C.
Dorian Randel E.
Jemtrud Susan A.
Azpuru C.
Dolezalova Hana
Page Thurman K.
The Regents of the University of California
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