Non-dissolvable drug-containing dosage-forms for use in the tran

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical

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424439, 424441, 514948, A61K 968

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active

058559086

ABSTRACT:
Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to manufacturing techniques that enable therapeutic agents to be incorporated into nondissolvable drug containment matrixes which are capable of releasing the drug within a patient's mouth. An appliance or holder is preferably attached to the drug containment matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The nondissolvable drug containment matrix may include permeation enhancers to increase the drug absorption by the mucosal tissues of the mouth. The matrix composition may also include pH buffering agents to modify the salival pH thereby increasing the absorption of the drug through the mucosal tissues.

REFERENCES:
patent: 122507 (1872-01-01), Wills
patent: 1430642 (1922-10-01), Gross
patent: 1593858 (1926-07-01), Venable
patent: 1847415 (1932-03-01), Snell
patent: 1915614 (1933-06-01), Parker
patent: 1971560 (1934-08-01), Guyon
patent: 2096611 (1937-10-01), Ellestad
patent: 2246778 (1941-06-01), Cahoon
patent: 2295042 (1942-09-01), Llewellyn
patent: 2323656 (1943-07-01), Helfestein
patent: 2388533 (1945-11-01), Edmondson et al.
patent: 2469589 (1949-05-01), Barricini
patent: 2488272 (1949-11-01), Davis
patent: 2499734 (1950-03-01), Edmondson et al.
patent: 2508560 (1950-05-01), Adams
patent: 2553446 (1951-05-01), Edmondson et al.
patent: 2897624 (1959-08-01), Yakel et al.
patent: 2915061 (1959-12-01), Edmondson et al.
patent: 2926121 (1960-02-01), Hobbs et al.
patent: 2963404 (1960-12-01), Hammer et al.
patent: 3169907 (1965-02-01), Heusser et al.
patent: 3172179 (1965-03-01), Schafer
patent: 3192924 (1965-07-01), Edmondson et al.
patent: 3210247 (1965-10-01), Suranyl
patent: 3264115 (1966-08-01), Davis
patent: 3271256 (1966-09-01), Frey
patent: 3344030 (1967-09-01), Stevens et al.
patent: 3399673 (1968-09-01), Jones et al.
patent: 3418743 (1968-12-01), Halvorsen
patent: 3429308 (1969-02-01), Russell
patent: 3493652 (1970-02-01), Hartman
patent: 3556811 (1971-01-01), Smith
patent: 3797494 (1974-03-01), Zaffaroni
patent: 3816953 (1974-06-01), Hameen-Anttilla
patent: 3867927 (1975-02-01), Hergott
patent: 3943928 (1976-03-01), Lariccia et al.
patent: 3996934 (1976-12-01), Zaffaroni
patent: 4060084 (1977-11-01), Chandrasekaran et al.
patent: 4093709 (1978-06-01), Choi et al.
patent: 4131648 (1978-12-01), Choi et al.
patent: 4138344 (1979-02-01), Choi et al.
patent: 4139627 (1979-02-01), Lane et al.
patent: 4168308 (1979-09-01), Wretlind et al.
patent: 4169885 (1979-10-01), Raaf et al.
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4292299 (1981-09-01), Suzuki et al.
patent: 4307075 (1981-12-01), Martin
patent: 4311722 (1982-01-01), Vink et al.
patent: 4346709 (1982-08-01), Schmitt
patent: 4372942 (1983-02-01), Cimiluca
patent: 4389393 (1983-06-01), Schor et al.
patent: 4390520 (1983-06-01), Nagai et al.
patent: 4452825 (1984-06-01), Klacik et al.
patent: 4466953 (1984-08-01), Keith et al.
patent: 4470962 (1984-09-01), Keith et al.
patent: 4482534 (1984-11-01), Blank
patent: 4485087 (1984-11-01), Otsuka et al.
patent: 4515769 (1985-05-01), Merritt et al.
patent: 4517173 (1985-05-01), Kizawa et al.
patent: 4529589 (1985-07-01), Davydov et al.
patent: 4551329 (1985-11-01), Harris et al.
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4588580 (1986-05-01), Gale et al.
patent: 4671953 (1987-06-01), Stanley et al.
patent: 4749575 (1988-06-01), Rotman
patent: 4885173 (1989-12-01), Stanley et al.
Brown, Absorption of Analgesics From the Buccal Mucous Membrane, 196 The Practitioner 125 (1966).
Beckett et al., "Buccal Absorption of Basic Drugs and Its Application as an In Vivo Model of Passive Drug Transfer Through Lipid Membranes", 19 J. Pharm. Pharmac, 31S (1967).
Dearborn et al., "Buccal Absorption as a Parameter of Analgesic Activity of Some P-substituted Acetanilides," 23 Journal Pharm.Pharmac. 73S (1971).
Dollery et al. "Differences in The Metabolism of Drugs Depending Upon Their Routes of Administration," 179 Annals of the New York Academy of Sciences 108 (1971).
Dopkin, "Buprenorphine Hydrochloride: Determination of Analgesic Potency," 24 Canadian Anaesthesiology Society Journal 186 (1977).
Edge et al., "Analgesic Effects of Sublingual Buprenorphine," 34 Anaesthesia 463 (1979).
Fry, "Relief of Pain After Surgery," 34 Anaesthesia 549 (1979).
Bullingham et al, "Sublingual Buprenorphine Used Postoperatively: Clinical Observations and Preliminary Pharmacokinetic Analysis," 12 Br. J. Clin. Pharmac. 117 (1981).
Ellis et al., "Pain Relief After Abdominal Surgery--A Comparison of I.M. Morphine, Sublingual Buprenorphine and Self-Administer I.V. Pethidine," 54 Br. J. Anaesth. 421 (1982).
Port et al., "Topical Narcotic Anesthesia," 59 Anesthesiology (1983).
Windholz et al., "The Merck Index," published by Merck & Co., Inc., pp. 575, 795, 796, and Appendix 3 (1983).
Abrams, "New nitrate delivery systems" Buccal nitroglycerin, vol. 105 American Heart Journal, pp. 848-854 (1983).
White et al. "Comparative Pharamocology of Intravenous Anesthetics --A Model for Determining Dosage Requirements and Therapeutic Concentration Ranges During Surgery," 59 Anesthesiology, A379 (1983).
Asthana et al., "Verapamil Disposition and Effect on PQ-Intervals After Buccal, Oral and Intravenous Administration," Arzneim.-Forsch./Drug Res., pp. 498-502 (1984).
Derbyshire et al., "Non-Parenteral Postoperative Analgesia," Anesthesia 39, pp. 324-328 (1984).
DeBoer et al., "Drug Absorption by Sublingual and Rectal Routes," 56 British Journal of Anaesthesiology 69 (1984).
Stanley et al., "The Effect of Population Habits on Side Effects and Narcotic Requirements During High-Dose Fentanyl Anaesthesia," 31 Can Anaesth Soc J 398 (1984).
Bailey et al., "Anesthetic Induction with Fentanyl, " 64 anesth Analg 48 (1985).
Huttel et al., "Sublingual unitrazepam for Premedication," Acta Anaesthesiol Scnd. 29, pp. 209-211 (1985).
Risbo et al., "Sublingual Buprenorphine for Premedication and Postoperative Pain Relief in Orthopedic Surgery," Acta Anaesthesiol Scand. 29, pp. 180-182 (1985).
Risbo et al., "Sublingual Buprenorphine for Premedication and Postperative Pain Relief in Orthopedic Surgery," Acta Anaesthesiol Scand. 29, pp. 180-182 (1985).
Bell et al., "Buccal Morphine--A New Route for Analgesia?" The Lancet 71 (1985).
Schechter et al., "Status of Pediatric Pain Control: A Comparison of Hospital Analgesic Usage in Children and Adults," 77 Pediatrics 11 (186).
Bailey et al., "Pharmacology of Intravenous Narcotic Anesthetics,"in Anesthesia 2nd ed. (Miller ed. 1986).
Forbes et al., "2% Rectal Methohexital for Induction of Anesthesia in Children," vol. 65 Anesthesiology No. 3 (Sep. 1986).
Newspaper article entitled "Insulin Shots May Soon be Replaced by a Nasal Spray," Friday, Sep. 26, 1986 (UPI).
"New Drugs/Drug News," Hospital Therapy, pp. 9, 10,and 15 (Nov. 1986).
Davis, "Parenteral Therapy Techniques-Abstracts," Hospital Pharmacy, vol. 21, pp. 1171-1178 (Dec. 1986).
"Personalized Dosing and Effective Drugs can Control Emesis,"Pharmacy Practice News, p. 11 ( Mar. 1987).
"Administration of Drugs by the Buccal Route," The Lancet, pp. 666-667 (Mar. 21, 1987).
Lee, "Ophthalmic Delivery of Peptides and Proteins," Pharmaceutical Technology, pp. 26-38 (Apr. 1987).
Grover et al., "Low-does Intranasal Nitroglycerine Attenuates Pressor Reponse," 66 Anesthesiology, p. 722 (1987).
White et al., "Comparative Pharamacology of Intravenous Anesthetics --A Model for Determining Dosage Requirements and Therapeutic Concentration Ranges During Surgery," 59 Anesthesiology, A379 (Sep. 1983).
Stanley et al., "The

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