Non-depleting anti-CD4 monoclonal antibodies and tolerance induc

Details Non-depleting anti-CD4 monoclonal antibodies and tolerance induc Non-depleting anti-CD4 monoclonal antibodies and tolerance induc

1995-06-06

2000-05-02

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241431, 4241531, 4241541, 4241731, 514 11, A61K 39395, A61K 3702

Patent

active

060569565

ABSTRACT:
Tolerance to an antigen is induced in a subject by administering a non-depleting CD4 monoclonal antibody and a non-depleting CD8 monoclonal antibody. Tolerance to the antigen can be induced under cover of these antibodies. A depleting CD4 monoclonal antibody and/or a depleting CD8 monoclonal antibody may be administered prior to the non-depleting antibodies.

REFERENCES:
patent: 4681760 (1987-07-01), Fathman
patent: 4695459 (1987-09-01), Steinman et al.
patent: 5690933 (1997-11-01), Cobbold et al.
M. Bartholomew, et al, "Functional Analysis of the Effects of a Fully Humanized anti-CDR Antibody on Resting and activated Human T Cells", Immunology 85:41 (1995), pp. 41-48.
Yedida Sharabi, et al, "Mixed Chimerism and Permanent Specific Transplantation Tolerance Induced by a Nonlethal Preparative Regimen", The Journal of Experimental Medicine, vol. 169, Feb. 1989, pp. 493-502.
Schmidt et al. Nervenarzt 67: 170-176 (1996).
Schmidt et al. Nervenarzt 67: 170-176 (1996) English translation.
Levy et al. Arthritis Rheumatsm 39(9 suppl) S122, 1996 #574.
Choy et al. Arthritis Rheumatym 39(9 suppl) S244, 1996 #1301.
Panayi et al. Arthritis Rheumatsm 39(9 suppl) S244, 1996 #1300.
Connolly et al. Arthritis Rheumatism 39 (9 suppl) S245, 1996 #1302.
Watson et al. Tissue Antigens 43: 155-162 (1994).
Watson et al. Transplant. Proc. 27(1): 123-124 (1995).
Bach et al. Immunol. Today 14: 421-425 (1993).
Russell et al BMJ 305: 1424-1429 (1997).
Nossol n Paul (ed) Fundamental Immunology 2.sup.nd Ed. Raven Press, NY 1989 pp 571-586.
Watson et al. J Surg. 80: 1389-1392 (1993).
Chen et al. Transplant Proc. 26: 2433-2434 (1994).
Jolliffe Intern Riv Immunol. 10:241-250 (1993).
Waldmann Am I Kid Dis XI(2) 154-158 (1988).
I. Harris et al. TIBTECH 11: 42-44 (1993).
Waldmann Science 252: 1657-1662 (1989).
Riethmuller et al., Immunological Series, 59, Ed. Bach, pp. 261-269 (1993).
Morel et al., Immunological Series, 59, pp. 271-276 (1993).
Riethmuller et al., Immunological Reviews 1992, No. 129, pp. 81-104.
Benjamin et al., J. Exp. Med., 163 (1986), pp. 1539-1552.
Benjamin and Waldmann, Nature 320 (1986), pp. 449-451.
Benjamin et al., Eur. J. Immunol. 18 (1988), pp. 1079-1088.
Carteron et al., J. Immunol. 140 (1988) pp. 713-716.
Cobbold et al., Nature 312 (1984) pp. 548-551.
Cobbold et al., Eur. J. Immunol. 20 (1990) pp. 2747-2755.
Goronzy et al., J. Exp. Med. 164 (1986) pp. 911-925.
Gutstein et al., J. Immunol. 137 (1986) pp. 1127-1132.
Gutstein and Wofsey, J. Immunol. 137 (1986) pp. pp. 3414-3419.
Kirkman et al., J. Exp. Med., 162 (1985), pp. 358-362.
Qin et al., J. Exp. Med. 169 (1989), pp. 779-794.
Qin et al., Eur. J. Immunol. 20 (1990), pp. 2737-2745.
Ranges et al., J. Exp. Med. 162 (1985), pp. 1105-1110.
Sedgwick et al., J. Neuroimmunol., 13 (1986), pp. 217-222.
Waldmann, Annual Reviews Immunology 7 (1989), pp. 407-444.
Waldor et al., Science 227 (1985), pp. 415-417.
Wofsey et al., J. Immunol. 134 (1985), pp. 852-856.
Wofsey et al., J. Immunol. 135 (1985), pp. 1698-1701.
Wofsey and Seaman, J. Exp. Med. 161 (1985), pp. 378-391.
Waldmann et al in Progress in Immunology vol. VII, Proceedings of the 7th International Congress of Immunology Berlin 1989, F. Melchers et al., eds, Springer-Verlag (1989), pp. 147-155.
Waldmann et al., in Cold Spring Harbor Symposium on Quantitative Biology:Immunological Recognition LIV, Cold Spring Harbor Laboratory Press (1989), pp. 885-892.
Jonker et al., Transplant Proc. XIX (1987), pp. 4308-4314.
Charlton et al., Immunol. Cell Biol. 67(1) (1989), pp. 1-7.
Carteron et al.,, J. Immunol., 142,(1989), pp. 1470-1475.
Qin et al., Eur. J. Immunol., 17 (1987), pp. 1159-1165.

Affiliated with

Also associated with

Rating

Non-depleting anti-CD4 monoclonal antibodies and tolerance induc does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-depleting anti-CD4 monoclonal antibodies and tolerance induc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-depleting anti-CD4 monoclonal antibodies and tolerance induc will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1591932