Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-04-26
2005-04-26
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S096000
Reexamination Certificate
active
06884799
ABSTRACT:
The present invention relates to novel pyrrolo[2,1-c][1,4]benzodiazepines compounds of general formula V as shown below, which are useful as potential antitumour agents and a process of preparing these compounds; particularly the present invention provides a process for the preparation of 7-methoxy-8-{n-[7-methoxy-(11aS)-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]ben-zodiazepine-5-one-8-yloxy]alkyloxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one, with varying aliphatic chain length and its 2-hydroxy derivatives.
REFERENCES:
patent: 6362331 (2002-03-01), Kamal et al.
patent: WO 9318045 (1993-09-01), None
A. Kamal et al., “Design, Synthesis, and Evaluation of New Noncross-Linking Pyrrolobenzodiazepine Dimers with Efficient DNA Binding Ability and Potent Antitumor Activity”, J. Med. Chem. 2002, 45, 4679-4688.
D. Thurston et al., “Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c] [1,4]benzodiazepine DNA Interstrand Cross-Linking Agents”, J. Org. Chem., 1996, 61, 8141-8147.
Kamal Ahmed
Ramesh Gujjar
Ramulu Poddutoori
Srinivas Olepu
Birch & Stewart Kolasch & Birch, LLP
Council of Scientific and Industrial Research
Kifle Bruck
LandOfFree
Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3437534