Non-covalent inhibitors of AmpC β-lactamase

Details Non-covalent inhibitors of AmpC β-lactamase Non-covalent inhibitors of AmpC β-lactamase

2003-02-19

2009-06-02

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S059000, C549S062000

Reexamination Certificate

active

07541381

ABSTRACT:
β-lactamases are the most widespread resistance mechanism to β-lactam antibiotics, such as penicillins and cephalosporins. In response to these enzymes, inhibitors have been introduced. Unfortunately, these inhibitors are also β-lactams, and resistance to them has developed rapidly. Consequently, the present invention provides a novel structure-based approach to inhibitors of these enzymes.

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