Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1986-09-24
1991-04-02
Drarer, Garnette D.
Drug, bio-affecting and body treating compositions
Lymphokine
424 8591, 424 86, 424 87, 424 88, 530387, 530388, 530389, 514 2, 514885, A61K 3700, A61K 3900
Patent
active
050046063
ABSTRACT:
A composition comprising a non-covalent immunocomplex of an anthracycline agent and an antibody selected to bind a target antigen and enhance the cytotoxicity of the anthracycline agent is disclosed. In accordance with the invention, the efficacy of an anthracycline as an anti-tumor agent for use in in vivo therapy is enhanced by administering to a patient a non-covalent immunocomplex provided herein.
REFERENCES:
patent: 4093607 (1978-06-01), Sela et al.
patent: 4263279 (1981-04-01), Sela et al.
patent: 4401592 (1983-08-01), Yoshikumi et al.
patent: 4520226 (1985-05-01), Neville et al.
patent: 4671958 (1987-06-01), Rodwell et al.
Zaharko et al, Methods in Cancer Res., XVI, 1979, pp. 347-380.
Hurwitz et al, Int. J. Cancer 21, 1978, pp. 747-755.
Thorpe, Monoclonal Antibodies, 1985; ed. Pinchera et al, pp. 475-506.
Ghose et al, Methods in Enzymology, vol. 93, 1983, pp. 280-333.
Hurwitz et al, J Applied Biochem. 1980 (2), pp. 25-35.
Suzuki et al, Chem Pharm. Bull., 29(3), 1981, pp. 844-848.
Rowland et al, Monoclonal Antibodies for Cancer Detection and Therapy, 1985, ed. Baldeuin et al, Chapter 17, pp. 345-364.
Sullivan et al, PNAS 1986, pp. 6117-6121.
Denei et al, Science, 1986, pp. 148-150.
Webbs et al, CA, vol. 104, 1986, #199671p.
Site-Specific Drug Delivery, ed. Tomlinson et al, 1986, pp. 93-110, (Davis et al.).
Monoclonal Antibodies and Cancer Therapy, ed. Reisfeld et al, 1985, pp. 243-256, Arnon, et al.
Hurwitz, et al., Int. J. Cancer, 21, 747 (1978).
Bartholomew Richard M.
Dillman Robert O.
Frincke James M.
Brown Theresa A.
Drarer Garnette D.
Hybritech Incorporated
Sherman Ronni L.
Steinhardt Paul C.
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