Non-contaminating direct serum assay of steroid hormones

Details Non-contaminating direct serum assay of steroid hormones Non-contaminating direct serum assay of steroid hormones

1981-09-18

1984-10-16

Nucker, Christine M.

Chemistry: analytical and immunological testing

Immunochemical pregnancy determination

436536, 436542, 436826, 436817, 436825, G01N 3356, G01N 3358

Patent

active

044775776

ABSTRACT:
A method for direct serum assay of steroid hormones wherein the competition from binding protein, having an affinity for complexing with the steroid hormones, is significantly eliminated by adding to the serum an artificial compound which has a greater or equal affinity for the binding protein than do the steroid hormones, and which is not immuno-reactive with the steroid hormones. Because the compound is artificial, it is non-contaminating. Levonorgestrel and norethindrone as such compounds are disclosed.

REFERENCES:
patent: 4208400 (1980-06-01), Edwards
patent: 4225574 (1980-09-01), Romelli et al.
patent: 4311690 (1982-01-01), Buehler et al.
patent: 4366143 (1982-12-01), Midgley et al.

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