Non-capsulated mutants of Actinobacillus pleuropneumoniae useful

Details Non-capsulated mutants of Actinobacillus pleuropneumoniae useful Non-capsulated mutants of Actinobacillus pleuropneumoniae useful

1993-06-24

1995-07-04

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424825, 435245, 435243, A61K 39102, C12N 136

Patent

active

054298180

ABSTRACT:
Noncapsulated mutants of normally encapsulated bacteria in which the capsule is required for virulence are useful as vaccines for disease states caused by the normally encapsulated bacteria. In particular, a non-capsulated mutant of Actinobacillus (Haemophilus) pleuropneumoniae is useful in protecting against swine pleuropneumonia.

REFERENCES:
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Inzana et al., Infection and Immunity, 55:1580-1587 (1987) H. pleuropneumoniae.
Inzana et al., Infect. Immun., 56:1880-1889 (1988) A. pleuropneumoniae.
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Inmana et al., J. Clin, Micr., 28:1356-1361 (1990) (ELISA).
Inzana et al., Micro. Path., 10:281-296 (1991) A. pleuropneumoniae.
Rosendal et al., Am. J. Vet. Res., 51:711-717 (1990) Capsule-Deficient Mutant of serotype 1 A. pleuropneumoniae.
Devenish et al., Infect. Immun., 58:3829-3832 (1990).
Inzana, 11th Cong. Proc. Int. Pig Vet. Soc., Switzerland, Jul. 1-5, 1990.
Ma, J. et al. (1989) Abstr. Annu. Meeting Am. Soc. Microbiol. B180, p. 60.

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