Non-basic melanin concentrating hormone receptor-1 antagonists

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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Details

C514S241000, C514S248000, C544S181000, C544S235000

Reexamination Certificate

active

07851622

ABSTRACT:
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula Iwhere R1, R1a, R1b, A, R3, R4, R5, R5band R6are as defined herein.

REFERENCES:
patent: 2007/0093509 (2007-04-01), Washburn et al.
patent: WO 03/033476 (2003-04-01), None
patent: WO 2005/042541 (2005-05-01), None
patent: WO 2005/103039 (2005-11-01), None
patent: WO 2007/011284 (2007-01-01), None
patent: WO 2007/011286 (2007-01-01), None
Wolft Manfred E. “Burger's Medicinal Chemistry, 5ed, Part 1”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutices, 3ed.”, Marcel Dekker, New York. 1996, pp. 451 and 596.
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Vippagunta et al., Advanced Drug Delivery Reviews 48: 3-26, 2001.
U.S. Appl. No. 12/473,346, filed May 28, 2009, Washburn, et al.

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