Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-04-18
2006-04-18
Campell, Bruce R. (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07030091
ABSTRACT:
The present invention provides compositions of matter which allow for the extended release and enhanced bioavailability of biologically-active polypeptides following parenteral delivery to an animal. More particularly, it concerns compositions comprising biologically-active somatotropin formulated for extended release, methods of preparing these compositions, and methods of using the same. These compositions comprise somatotropin, a pH-adjusting constituent (PAC), and a substantially non-aqueous, hydrophobic excipient. The PAC may comprise any suitable, biocompatible compound including, but not limited to one or mixtures of two or more of the following: acetic acid, phosphoric acid, monobasic phosphate. The PAC is added to the compositions of matter in an amount effective to adjust the pH to or near to the isoelectric point (pI) of the somatotropin component.
REFERENCES:
patent: 4816568 (1989-03-01), Hamilton et al.
patent: 4857506 (1989-08-01), Tyle
patent: 4917685 (1990-04-01), Viswanathan et al.
patent: 4977140 (1990-12-01), Ferguson et al.
patent: 5034229 (1991-07-01), Magruder et al.
patent: 5037420 (1991-08-01), Magruder et al.
patent: 5096885 (1992-03-01), Pearlman et al.
patent: 5219572 (1993-06-01), Sivaramakrishnan et al.
patent: 5356635 (1994-10-01), Raman et al.
patent: 5359030 (1994-10-01), Ekwuribe
patent: 5399489 (1995-03-01), Krivi
patent: 5438040 (1995-08-01), Ekwuribe
patent: 5474980 (1995-12-01), Mitchell
patent: 5520927 (1996-05-01), Kim et al.
patent: 5607691 (1997-03-01), Hale
patent: 5612315 (1997-03-01), Pikal et al.
patent: 5631227 (1997-05-01), Harbour
patent: 5681811 (1997-10-01), Ekwuribe
patent: 5739108 (1998-04-01), Mitchell
patent: 5744163 (1998-04-01), Kim et al.
patent: 5773588 (1998-06-01), Owsley et al.
patent: 5801141 (1998-09-01), Steber et al.
patent: 5849704 (1998-12-01), Sørensen et al
patent: 5972370 (1999-10-01), Echenhoff
patent: 5986073 (1999-11-01), Storrs et al.
patent: 6086918 (2000-07-01), Stern
patent: 6162258 (2000-12-01), Scarborough
patent: 0 216 485 (1987-04-01), None
patent: 0 278 103 (1988-08-01), None
patent: 0 303 746 (1989-02-01), None
patent: 0 374 120 (1990-06-01), None
patent: 0 523 330 (1993-01-01), None
patent: 0 913 177 (1999-05-01), None
patent: 3086834 (1991-04-01), None
patent: WO 89 09614 (1989-10-01), None
patent: WO 93/12812 (1993-07-01), None
patent: WO 93/13792 (1993-07-01), None
patent: WO 93/19773 (1993-10-01), None
patent: WO 97/03692 (1997-02-01), None
patent: WO 97/29767 (1997-08-01), None
patent: WO 98/29131 (1998-07-01), None
patent: WO 00/13674 (2000-03-01), None
Katakam, Manohar:Use of non-ionic surfactants to stabilize recombinant human growth hormone and to develop its sustained release formulation, Diss. Abstr. Int., vol. 57, No. 5, 1996, p. 3149.
Heintz Daniel N.
Jeng Yunhua N.
Bonner Grace L.
Campell Bruce R.
Howrey LLP
Monsanto Technology LLC
Teller Roy
LandOfFree
Non-aqueous injectable formulation preparation with pH... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Non-aqueous injectable formulation preparation with pH..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-aqueous injectable formulation preparation with pH... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3524572