Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1997-03-31
2000-12-19
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424451, 424464, 424465, A61K 948, A61K 920
Patent
active
061624640
ABSTRACT:
Orally administered colonic purgative formulations and methods of its use for effecting partial or complete purgation of the colon in mammals, the formulations consisting of non-aqueous admixtures of a purgative salt selected from the group consisting of Mg.sub.3 (PO.sub.4).sub.2, MgHPO.sub.4, Mg(H.sub.2 PO.sub.4).sub.2, MgSO.sub.4, MgCl.sub.2, Na.sub.2 SO.sub.4, sodium tartrate, potassium tartrate, magnesium tartrate and mixtures, thereof, administered in tablet or capsule form in purgative effective concentrations. Preferred embodiments make use of at least one or more magnesium phosphate salts, more preferably dibasic magnesium phosphate; other preferred embodiments include the addition of binders, dispersants and buffers which do not adversely affect osmolality or effectiveness of the purgative formulations.
REFERENCES:
patent: 3088870 (1963-05-01), McDermott
patent: 3676553 (1972-07-01), Reynolds
patent: 3821368 (1974-06-01), Reynolds
patent: 4104370 (1978-08-01), Bloch
patent: 4432966 (1984-02-01), Zeitoun
patent: 4452779 (1984-06-01), Cockerill
patent: 4665100 (1987-05-01), Ludwig
patent: 4725427 (1988-02-01), Ashmend et al.
patent: 4812311 (1989-03-01), Uchtoman
patent: 4842871 (1989-06-01), Hill
patent: 4904474 (1990-02-01), Theeuwes
patent: 4959222 (1990-09-01), Nadland
patent: 5108758 (1992-04-01), Allwood
patent: 5124144 (1992-06-01), Giorgetti
patent: 5616346 (1997-04-01), Aronchick
patent: 5858403 (1999-01-01), Borody et al.
Physician's Desk Reference; pp. 608-609, 1995 Ed.
Physician's Desk Reference; pp. 699-700; 922-993; & 1826-1827; 1992.
Corazziari, Small Volume Isosmotic Polyethylene Glycol Electrolyte Balanced Solution (PMF-100) in Treatment of Chronic Nonorganic Constipation, Digestive Diseases and Sciences, 41:1636-1642 (1996).
Izzo, The Osmotic and Intrinsic Mechanisms of the Pharmacological Laxative Action of Oral High Doses of Magnesium Sulphate: Importance of the Release of Digestive Polypeptides and Nitric Oxide, Magnesium Research, 9:133-138 (1996).
Liacouras, Whole-Bowel Irrigation as an Adjunct to the Treatment of Chronic, Relapsing Clostridium Difficile Colitis, J. Clin. Gastroenterology, 22:186-189 (1996).
Chapman, Antibacterial Activity of Bowel-Cleansing Agents: Implications of Antibacteroides Activity of Senna, Br. J. Surg., 82:1053 (1995).
Goldberg, A Study of a New Osmotic Purgative for Colonoscopy: Is Golytely.RTM. Worth its Salt!, Surgical Endoscopy, 9:329-331 (1995).
Izzo, Nitric Oxide as a Mediator of the Laxative Action of Magnesium Sulphate, Br. J. Pharmacol., 113:228-232 (1994).
Bergin, The Effect of Preliminary Bowel Preparation on a Simple Test of Colonic Transit in Constipated subjects, International Journal of Colorectal Disease, 8:75-77 (1993).
Martindale, The Extra Pharmacopoeia, 30.sup.th edition, 858-860 (Reynolds ed., 1993).
Araki, A Study of Polyethylene Glycol Electrolyte Lavage Solution and Sodium Picosulfate Combined Pretreatment Method of Colonoscopy, The Kurume Medical Journal, 39:117-121 (1992).
Jacob Leonard S.
Krell Robert D.
Williams Taffy J.
Inkine Pharmaceutical, Inc.
McQueeney P.
Page Thurman K.
LandOfFree
Non-aqueous colonic purgative formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Non-aqueous colonic purgative formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-aqueous colonic purgative formulations will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-269167