Non-antigenic toxin-conjugate and fusion protein of internalizin

Details Non-antigenic toxin-conjugate and fusion protein of internalizin Non-antigenic toxin-conjugate and fusion protein of internalizin

1997-10-14

2000-07-04

Mertz, Prema

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to lymphokine, cytokine, or other secreted growth...

424 111, 424 91, 424 851, 424 852, A61M 3614

Patent

active

060834773

ABSTRACT:
A conjugate of a toxin and a cytokine, and a fusion protein comprising a bispecific antibody that has a first specificity for a cell marker specific to a malignant cell and a second specificity for a region of IL-15.alpha., each optionally further comprising a radionuclide, are useful therapeutic reagents for treating leukemias and lymphomas.

REFERENCES:
patent: 4837003 (1989-06-01), Nicolotti
Anderson et al., "Functional Characterization Of The Human Interleukin-15 Receptor .alpha. Chain And Close Linkage Of IL154A And IL2RA Genes", The Journal of Biological Chemistry, vol. 270(50):29862-29868, (1995).
de Jong et al., "Interaction Of IL-15 With The Shared IL-2 Receptor .beta. And .gamma..sub.c Receptor-Ligand Complex", The American Association of Immunologists, vol. 156(4):1339-1348, (1996).
Chae et al., "Distribution Of IL-15 Receptor .alpha.-Chains On Human Peripheral Blood Mononuclear Cells And Effect Of Immunosuppressive Drugs On Receptor Expression", The Journal Of Immunology, vol. 157(7):2813-2819, (1996).

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