Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to lymphokine – cytokine – or other secreted growth...
Reexamination Certificate
2006-04-25
2006-04-25
Mertz, Prema (Department: 1646)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to lymphokine, cytokine, or other secreted growth...
C424S001110, C424S009100, C424S085100, C424S085200, C424S130100, C424S144100, C424S184100, C424S192100, C514S002600, C514S008100, C514S012200, C530S387100, C530S387300, C530S388220
Reexamination Certificate
active
07033572
ABSTRACT:
A conjugate of a toxin and a cytokine, and a fusion protein comprising a bispecific antibody that has a first specificity for a cell marker specific to a malignant cell and a second specificity for a region of IL-15α, each optionally further comprising a radionuclide, are useful therapeutic reagents for treating leukemias and lymphomas.
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patent: 6083477 (2000-07-01), Goldenberg
patent: WO 92/00762 (1992-01-01), None
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patent: WO 94/07535 (1994-04-01), None
patent: WO 95/30695 (1995-11-01), None
patent: WO 96/26274 (1996-08-01), None
Anderson et al., “Functional characterization of the Human Interleukin-15 Receptor α Chain and Close Linkage of IL5RA and IL2RA Genes”, The Journal of Biological Chemistry, vol. 270(50), pp. 29862-29868, (1995).
de Jong et al., “Interaction of IL-15 with the Shared IL-2 Receptor β and γcReceptor-Ligand Complex”, The American Association of Immunologists, vol. 156(4), pp. 1339-1348, (1996).
Chae et al., “Distribution of IL-15 Receptor α -Chains on Human Peripheral Blood Mononuclear Cells and Effect of Immunosuppressive Drugs on Receptor Expression”, The Journal of Immunology, vol. 157(7), pp. 2813-2819, (1996).
“The Merck Manual of Diagnosis & Therapy”, Burns & Berkov Published by Merck Research Labs, 17thedition (1999).
Heller Ehrman LLP
Immunomedics Inc.
Mertz Prema
LandOfFree
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