Stock material or miscellaneous articles – Web or sheet containing structurally defined element or... – Composite having voids in a component
Patent
1978-09-25
1980-11-11
Goolkasian, John T.
Stock material or miscellaneous articles
Web or sheet containing structurally defined element or...
Composite having voids in a component
106155, 106161, 128156, 128334R, 128335, 128DIG8, 156 78, 2601237, 424 28, 424177, 427180, 427244, 427389, 428316, 428317, 428332, 4284782, B32B 526, A61L 1504, C08L 8906
Patent
active
042333601
ABSTRACT:
Collagen, available from domestic animals, is freed of noncollagen proteins, glycosaminoglycans and lipids by enzymatic treatment with a proteolytic enzyme to yield a product which is soluble in dilute acidic aqueous solutions (collagen in solution--CIS). The naturally occurring collagen is modified by removal of certain terminal peptide chains, which are described as telopeptides. The modified collagen, so derived, is described as atelopeptide collagen. Native collagen is immunogenic, while atelopeptide collagen is nonimmunogenic or possessed of a negligibly low level of immunogenicity.
The collagen in solution is then treated according to a specific regimen under conditions whereby the collagen slowly separates from solution while exposed to mild shear forces. This procedure results in the formation of a fibrous precipitate composed of regularly ordered fibers of collagen possessed of a ropelike structure. These resulting aggregates are referred to as native fibrous micropolymers (NFM). Once the regimen or procedure is completed, and the fiber mass has been formed, the fibrous micropolymers may be freed of salt, taken up in a different solution or modified. For example, cross-links may then be introduced to stabilize the fibers. The products find wide use as packing, membranes, fibers, bags, supports, integuments, and are especially suitable for biologic implantation or application.
REFERENCES:
patent: 3491760 (1970-01-01), Braun et al.
patent: 3632361 (1972-01-01), Battista
patent: 4089333 (1978-05-01), Utsuo et al.
Daniels John R.
Luck Edward E.
Collagen Corporation
Dawson Robert A.
Goolkasian John T.
Rowland Bertram I.
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