Non-anticoagulant heparin derivatives

Details Non-anticoagulant heparin derivatives Non-anticoagulant heparin derivatives

1991-03-29

1993-10-05

Husarik, Nancy S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 536 21, 536 53, 536 553, 536124, A61K 31725, C08B 3710

Patent

active

052505197

ABSTRACT:
A non-anticoagulant (NAC) form of heparin which shows antiproliferative activity with respect to smooth muscle cells is useful in the prevention of restenosis and other conditions benefited by antiproliferative activity with respect to smooth muscle cells. This NAC form of heparin is prepared by deacetylating and then oxidizing heparin/heparan sulfate substantially to completion with periodate followed by reduction of the resulting aldehyde groups under conditions which prevent depolymerization of the heparin.

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