Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-04-11
1999-04-20
Housel, James C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4241841, 4241991, 4242041, 4351723, 4352531, 935 14, 935 29, 935 41, 935 45, C12P 2104, A61K 39003, C12N 1500, C12N 112
Patent
active
058957561
ABSTRACT:
The present invention provides a Mycobacterium-E. coli shuttle vector containing sequences coding for a tribrid fusion containing the M. leprae 18kDa antigen sequence, a phoA protein antigen sequence and a non-mycobacterial, non-E.coli heterologous protein antigen sequence. Also provided is a method of producing protective immunity in an animal or human host in need of such treatment, comprising the step of administering to said animal or human host an effective dose of recombinant mycobacteria carrying the vector of the present invention.
REFERENCES:
patent: 4769327 (1988-09-01), Stephens et al.
patent: 5514375 (1996-05-01), Paoletti et al.
Jacobs et al, "Mycobacteriophage vector systems", Reviews of Infectious Diseases, vol. 11, supplement 2, pp. s404-s410, Mar. 1, 1989.
Dellagostin et al "Construction and use of integrative vectors to express foreign genes in mycobacteria", Molecular Microbiology, vol. 10, No. 5, pp. 983-993, Sep. 1, 1993.
Kremer et al, "analysis of the Mycobacterium tuberculosis 85 A antigen promoter region", Journal of Bacteriology, vol. 177, No. 3, pp. 642-653, Feb. 1, 1995.
Barrett Alan D. T.
Ni Haolin
Niesel David
Robb Christopher
Adler Benjamin Aaron
Housel James C.
Swartz Rodney P.
The Board of Trustees of the University of Texas System
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