Non-antibiotic intervention of chlamydial infection

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S419000, C514S682000, C424S433000, C424S422000, C424S430000

Reexamination Certificate

active

07863335

ABSTRACT:
Methods for treating or reducing the risk of transmission ofchlamydiato a recipient by topically applying a metalloprotease inhibitor to a site on the recipient which is likely to be exposed toChlamydia. Topical compositions containing metalloprotease inhibitors are also disclosed for treating or reducing the risk of transmission ofChlamydia, as well as barrier contraceptive devices coated therewith.

REFERENCES:
patent: 4446860 (1984-05-01), Gutnick
patent: 2003/0113726 (2003-06-01), Tsuchihashi et al.
patent: 2004/0235886 (2004-11-01), Charifson et al.
Ault et al. “Chlamydia trachomatis enhances the expression of matrix metalloproteinases in an in vitro model of the human fallopian tube infection” Am J Obstet Gynecol, Nov. 2002, vol. 187, pp. 1377-1383.
Brown, P.D. “Matrix metalloproteinase inhibitors” Angiogenesis, 1997, vol. 1, pp. 142-154.
Duesbery, N.S. et al., Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor, J. Science, May 1, 1998, pp. 734-737, vol. 280.
Fan, H. et al., Characterization of Growth Factor-induced Serine Phosphorylation of Tumor Necrosis Factor-alpha Converting Enzyme and of an Alternatively Translated Polypeptide, J. Biological Chemistry, May 16, 2003, pp. 18617-18627, vol. 278, No. 20.
Fan, H. et al., Acquisition and Synthesis of Folates by Obligate Intracellular Bacteria of the Genus Chlamydia, J. Clinical Investigation, Nov. 1992, pp. 1803-1811, vol. 90.
Fan. H. et al., Biochemical Evidence for the Existence of Thymidylate Synthase in the Obligate Intracellular Parasite Chlamydia trachomatis, J. Bacteriology, Nov. 1991, pp. 6670-6677, vol. 173, No. 21.
Levy D.E. et al., Matrix Metalloproteinase Inhibitors: A structure—Activity Study, J. Med. Chem., Jan. 15, 1998, pp. 199-223, vol. 41.
Lopez-Otin, C. et al., Protease Degradomics: A New Challenge for Proteomics, Nature Reviews: Molecular Cell Biology, Jul. 2002, pp. 509-519, vol. 3.
Moulder, J.W., Interaction of Chlamydiae and Host Cells In Vitro, Microbiological Reviews, Mar. 1991, pp. 143-190, vol. 55, No. 1.
Oguma, K. et al., Structure and Function ofClostridium botulinumToxins, Microbiological Immunology, 1995, pp. 161-168, vol. 39, No. 3.
Schachter, J., Chapter 6: Infection and Disease Epidemiology in Chlamydia: Intracellular Biology, Pathogenesis, and Immunity, Edited by R.S. Stephens, 1999, pp. 139-169, American Society for Microbiology, Washington D.C.
Steele-Mortimer, O. et al., The invastion-associated Type III Secretion System ofSalmonella entericaserovar Typhimurium is Necessary for Intracellular Proliferation and Vacuole Biogenesis in Epithelial Cells, J. Cellular Microbiology, 2002, pp. 43-54, vol. 4, No. 1.
Stephens, R. S. et al., Genome Sequence of an Obligate Intracellular Pathogen of Humans:Chlamydia trachomatis, J. Science, Oct. 23, 1998, pp. 754-759, vol. 282.
Zhong, G. et al., Identification of a Chlamydial Protease-like Activity Factor Responsible for the Degradation of Host Transciption Factors, J. Exp. Med., Apr. 16, 2001, pp. 935-942, vol. 193, No. 8.
Kontogiorgis, C.A. et al., “Matrix Metalloproteinase Inhibitors: A Review on Pharmacophore Mapping and (Q)Sars Results”, Current Medicinal Chemistry, 2005, vol. 12, pp. 339-355.
Chen, S. et al., “Universal Screening or Prophylactic Treatment for Chlamydia trachomatis Infection Among Women Seeking Induced Abortionis: Which Strategy is More Cost-Effective?”, Sexually Transmitted Diseases, Apr. 2007, vol. 34, No. 4, pp. 230-236.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Non-antibiotic intervention of chlamydial infection does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Non-antibiotic intervention of chlamydial infection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Non-antibiotic intervention of chlamydial infection will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2627072

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.