Non-antibacterial tetracycline compositions possessing antiplaqu

Details Non-antibacterial tetracycline compositions possessing antiplaqu Non-antibacterial tetracycline compositions possessing antiplaqu

1991-02-11

1993-06-29

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

514152, A61K 716, A61K 3165

Patent

active

052232484

ABSTRACT:
A method of inhibiting plaque formation on mammalian tooth surfaces is disclosed. The method includes contacting the tooth surfaces with an effective amount of a non-antibacterial tetracycline. In a preferred embodiment, such tetracyclines are included in various oral hygiene products such as dentifrices, lozenges, chewing gums and the like to contact the tooth surfaces and prevent plaque accumulation thereon.

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patent: 4935412 (1990-06-01), McNamara et al.
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Sipos et al., "The Effect of Collagenase Inhibitors on Alveolar Bone Loss Due to Periodontal Disease in Desalivated Rats", Abstract, Matrix Metalloproteinase Conference, p. 48, Sep., 1989.
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Golub et al., "Low-dose Doxycycline Therapy: Effect on Gingival and Crevicular Fluid Collagenase Activity in Humans", Journal of Periodonal Research, 25, 321-330 (1990).
Golub et al., "In Vivo Crevicular Leukocyte Response To A Chemotactic Challenge: Inhibition by Experimental Diabetes", Infection and Immunity 37, 1013-1020 (1982).
Yu et al., "Serum Levels of Chemically-Modified tetracycline (CMT): A Comparison To Tetracycline (TC)", J. Dent. Res. 69, 245 (Special Issue) IADR Abstract No. 1092.

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