Non-antibacterial tetracycline compositions possessing anti-coll

Details Non-antibacterial tetracycline compositions possessing anti-coll Non-antibacterial tetracycline compositions possessing anti-coll

1985-02-07

1987-11-03

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

3,10-dihydroxy-2-naphthacene carboxamide or derivative doai

A61K 3165

Patent

active

047043830

ABSTRACT:
Tetracyclines having substantially no effective antibiotic or antibacterial activity and possessing anti-collagen-destructive enzyme activity or anti-collagenase activity and compositions containing the same have been found useful as anti-collagenolytic agents. Such tetracyclines and compositions containing the same are useful in the treatment of periodontal diseases, corneal ulcers, bone deficiency disorders, rheumatoid arthritis diseases characterized by excessive collagen destruction. A special aspect of this invention involves the incorporation of such tetracyclines in animal feed compositions for improved animal nutrition, such as may be evidenced by increased weight gain.

REFERENCES:
patent: 2895880 (1959-07-01), Rosenthal
patent: 3304227 (1967-02-01), Loveless
patent: 3636202 (1972-01-01), Klein
patent: 4371465 (1983-02-01), McGregor
patent: 4454110 (1984-06-01), Caslavsk et al.
Chemical Abstracts 100:96203a (1983).
Dreispach et al. Induchon of Collagenase Production in Vibrio B-30; J. Backeriol vol. 135, No. 2 (1978) pp. 521-527.

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