Non-adhesive ionene quaternary polymer compositions useful as bi

Details Non-adhesive ionene quaternary polymer compositions useful as bi Non-adhesive ionene quaternary polymer compositions useful as bi

1978-10-19

1980-01-22

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424329, A61K 3174

Patent

active

041850882

ABSTRACT:
The invention disclosed herein relates to novel non-adhesive, free-flowing, pharmacologically acceptable compositions comprising ionene quaternary polymers effective as bile acid sequestrants, such as poly-[{methyl-(3-trimethylammoniopropyl)iminio}trimethylene dichloride], adsorbed on a pulverulent, solid aggregate of large surface to mass ratio, such as fumed silicas and silica aerogels. It also relates to the novel process for preparing such adsorbate compositions which comprises forming a substantially, uniform suspension of the finely-divided solid aggregate in an aqueous solution of poly-[{methyl-(3-trimethylammoniopropyl)iminio}trimethylene dichloride], evaporatively removing the water from the suspension, and drying the adsorbate thus produced.

REFERENCES:
patent: 4016209 (1977-04-01), Wagner et al.
Chemical Abstracts 65:2071g (1966).
Chemical Abstracts 66:22211j (1967).
"Cab-O-Sil-Properties and Functions", Cabot Co., (8-1975).

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