Non-adenoviral gene product-based complementing cells for...

Details Non-adenoviral gene product-based complementing cells for... Non-adenoviral gene product-based complementing cells for...

2005-07-05

2005-07-05

Guzo, David (Department: 1636)

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

C435S456000, C435S325000, C435S366000, C435S369000, C435S320100

Reexamination Certificate

active

06913927

ABSTRACT:
The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which upon expression produces at least one non-adenoviral gene product that complements in trans for a deficiency in at least one essential gene function of one or more regions of an adenoviral genome so as to propagate a replication-deficient adenoviral vector comprising an adenoviral genome deficient in the at least one essential gene function of the one or more regions when present in the cell.

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