Non-A, non-B. hepatitis, virus, methods of identification purifi

Details Non-A, non-B. hepatitis, virus, methods of identification purifi Non-A, non-B. hepatitis, virus, methods of identification purifi

1984-02-08

1989-09-26

Hazel, Blondel

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

Monoclonal antibody

424 89, 424 858, G01N 3353, A61K 3942

Patent

active

048700266

ABSTRACT:
A purified form of a DNA virus which has the following characteristics: molecular weight greater than 2.times.10.sup.6 Daltons; substantial immunoreactivity towards an anti-HBsAg monoclonal antibody obtained from cell line ATCC HB 8058; substantially no immunoreactivity towards an anti-HBsAg monoclonal antibody obtained from cell line ATCC CRL 8018; concentration dependent immunoreactivity towards polyclonal IgG anti-HBsAg antibodies, which increases with increased concentration of said DNA virus; discrete particulate form when observed by immunoelectron microscopy in the presence of IgM antibodies from cell line ATCC HB 8058; the DNA of said virus showing hybridization with DNA from hepatitis B viral DNA; and said DNA virus showing, in chimpanzees, infectivity having the characteristics of non A, non B hepatitis.

REFERENCES:
patent: 4271145 (1981-06-01), Wands et al.
patent: 4291020 (1981-09-01), Tabor et al.
patent: 4356164 (1982-10-01), Tabor et al.
Robinson, "The Enigma of Non-A, Non-B Hepatitis", Journal of Infectious Diseases, vol. 145, No. 3, Mar. 1982.
Wands et al, The Lancet, Saturday, May 1, 1982.
Wands et al, Proceedings of the National Academy of Sciences USA, vol. 79, pp. 1277-1281 (Feb. 1982).
Tabor et al., Journal of Medicinal Virology 4:161-169 (1979).
Alter et al., 1981 International Symposium on Viral Hepatitis, ed. Szmuness et al.

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