Non-A, non-B hepatitis virus genomic cDNA and antigen polypeptid

Details Non-A, non-B hepatitis virus genomic cDNA and antigen polypeptid Non-A, non-B hepatitis virus genomic cDNA and antigen polypeptid

1997-08-01

1999-12-07

Wortman, Donna C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

530324, 530350, C12Q 170

Patent

active

05998130&

ABSTRACT:
Disclosed is an isolated non-A, non-B hepatitis virus genomic cDNA covering the entire region of the virus gene nucleotide sequence from the 1st to 9416th nucleotides shown in FIG. 2(1) through FIG. 2(16) hereof, wherein the coding region is from the 333rd to 9362nd nucleotides, and the 5'- and 3'- noncoding sequences contain 332 nucleotides and 54 nucleotides, respectively. Part of the cDNA and an antigen polypeptide as an expression product thereof are useful as a diagnostic reagent for non-A, non-B hepatitis. The antigen polypeptide is also useful as an active ingredient for a non-A, non-B hepatitis virus vaccine.

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Kato et al., "Molecular cloning of the human hepatitis C virus genome from apanese patients with non-A, non-B hepatitis", Proc. Natl. Acad. Sci. 87, 9524-9528, 1990.
Pharmacia P-L, Biochemicals Product Reference Guide 1984, Pharmacia P-L Biochemicals, Inc., Piscataway NJ, pp. 54, 58, 60.
Farci et al., "Lack of protective immunity against reinfection with hepatitis C virus", Science,, vol. 258, pp. 135-140, Oct. 1992.

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