Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptid

Details Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptid Non-A, non-B hepatitis virus genomic CDNA and antigen polypeptid

1994-10-18

1998-05-05

Knode, Marian C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Canine cell, per se

4241841, 4244861, 4241891, 4242041, 4242281, 435 71, 435 691, 435 693, 530350, 530403, 930223, A61K 3929, A61K 3900, A61K 3912, C07K 1400

Patent

active

057473390

ABSTRACT:
Disclosed is an isolated non-A, non-B hepatitis virus genomic cDNA covering the entire region of the virus gene nucleotide sequence from the 1st to 9416th nucleotides shown in FIG. 2(1) through FIG. 2(16) hereof, wherein the coding region is from the 333rd to 9362nd nucleotides, and the 5'- and 3'-noncoding sequences contain 332 nucleotides and 54 nucleotides, respectively. Part of the cDNA and an antigen polypeptide as an expression product thereof are useful as a diagnostic reagent for non-A, non-B hepatitis. The antigen polypeptide is also useful as an active ingredient for a non-A, non-B hepatitis virus vaccine.

REFERENCES:
patent: 4542016 (1985-09-01), Trepo
patent: 5350671 (1994-09-01), Houghton et al.
Farci et al., "Lack of Protective Immunity Against Reinfection with Hepatitis C Virus", Science 258, 135-140, 1992.
Kato et al., "Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis", Proc. Natl. Acad. Sci. 87, 9524-9528, 1990.

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