Non-a non-b hepatitis-specific antigen and its use in hepatitis

Details Non-a non-b hepatitis-specific antigen and its use in hepatitis Non-a non-b hepatitis-specific antigen and its use in hepatitis

1995-05-24

1997-09-02

Ketter, James

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4241891, 4242281, 530324, 530350, A61K 3929

Patent

active

056629060

ABSTRACT:
This invention relates to a DNA fragment comprising a base sequence encoding a non-A non-B hepatitis-specific antigen polypeptide, said base sequence being obtained using genetic engineering techniques from non-A non-B hepatitis virus RNA which is isolated directly from blood plasma from non-A non-B hepatitis patients, to an expression vector and a transformant for use in the expression of the DNA fragment, to a single strand DNA sequence for PCR primer, and to use of said polypeptide and said single strand DNA sequence in the detection of the non-A non-B hepatitis virus. The recombinant polypeptide and the single strand DNA sequence for PCR primer make it possible to detect the non-A non-B hepatitis virus with extremely high accuracy.

REFERENCES:
Kubo et al., Nucleic Acids Research, vol. 17, No. 24, 1989 pp. 10367-10372.
Okamoto et al., Japan J. Exp. Med., vol. 60, No. 3, 1990, pp. 167-177.
Kato et al., Proceedings of the National Academy of Sciences of the USA, vol. 87, No. 24, Dec. 1990, pp. 9524-9528.
Kato et al., Proc. Japan. Acad., vol. 65 Ser. 3, No. 1989, pp. 219-223.
Arima et al., Gastroenterologica Japonica, vol. 24, No. 5, 1989, pp. 540-544.
Ogata et al., Proceedings of the National Academy of Sciences of the USA vol. 88, No. 15, Apr. 1991 pp. 3392-3396.
Takamigawa et al., Journal of Virology, vol. 65, No. 3, Mar. 1991, pp. 1105-1113 Press (1979).
Choo et al., Proceedings of the National Academy of Sciences of the USA, vol. 88, Mar. 1991, pp. 2451-2455.
Arima et al., Gastroenterologia Japonica, vol. 24, No. 6, 1989, pp. 687-691.
Kubo et al. 1989. Nucleic Acids Research 17(24) 10367-10371.
Kato et al. 1989 Proc. Japan Acad. 65 SerB pp. 219-223.

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