Non-A non-B hepatitis specific antigen and its use in hepatitis

Details Non-A non-B hepatitis specific antigen and its use in hepatitis Non-A non-B hepatitis specific antigen and its use in hepatitis

1993-06-22

1997-06-24

Guzo, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525233, 4352525, 4352542, 4353201, 536 2372, C12P 2102, C12N 121, C12N 1571

Patent

active

056416547

ABSTRACT:
This invention relates to a DNA fragment comprising a base sequence encoding a non-A non-B hepatitis-specific antigen polypeptide, said base sequence being obtained using genetic engineering techniques from non-A non-B hepatitis virus RNA which is isolated directly from blood plasma from non-A non-B hepatitis patients, to an expression vector and a transformant for use in the expression of the DNA fragment, to a single strand DNA sequence for PCR primer, and to use of said polypeptide and said single strand DNA sequence in the detection of the non-A non-B hepatitis virus. The recombinant polypeptide and the single strand DNA sequence for PCR primer make it possible to detect the non-A non-B hepatitis virus with extremely high accuracy.

REFERENCES:
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Kato et al. Proceedings of the National Academy of Sciences of the USA, vol. 87, No. 24, Dec. 1990, pp. 9524-9528.
Kato et al., Proc. Japan Acad. vol. 65, Ser. B; Nov. 1989, pp. 219-223.
Arima et al., Gastroenterologia Japonica vol. 24 No. 5, 1989, pp. 540-544.
Ogata et al. Proceedings of the National Academy of Sciences of the USA vol. 88, No. 15, Apr. 1991, pp. 3392-3396.
Takamizawa et al., Journal of Virology, vol. 65, No. 3, Mar. 1991.
Choo et al., Proceedings of the National Academy of Sciences of the USA vol. 88, Mar. 1991, pp. 2451-2455.
Arima et al., Gastroenterologia Japonica, vol. 24, No. 6, 1989, pp. 687-691 .

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