Noise suppressing capillary separation system

Details Noise suppressing capillary separation system Noise suppressing capillary separation system

1995-03-20

1996-07-30

Niebling, John

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

204603, 356344, 356435, 73 6158, 73 234, G01N 2726, G01N 27447, G01N 2185, G01N 3062

Patent

active

055408257

ABSTRACT:
A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans.

REFERENCES:
patent: 2220231 (1972-04-01), Riebling
patent: 5047134 (1991-09-01), Weinberger et al.
patent: 5134276 (1992-07-01), Hobbs
patent: 5202006 (1993-04-01), Chen
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T. Higashijima et al., "Determination of Amino Acids by Capillary Zone Electrophoresis Based on Semiconductor Laser Fluorescence Detection," Anal. Chem., 64, 711-714 (1992).
P. C. D. Hobbs, "Reaching the Shot Noise Limit for $10," Optics and Photonics News, 17-23 (Apr. 1991).
P. C. D. Hobbs, "Shot Noise Limited Optical Measurements at Baseband with Noisy Lasers," SPIE Proc., 1376, 216-221 (1991).
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David M. Goodall et al, "Diode laser-based indirected absorbance detector for capillary electrophoresis" Journal of Chromatography 636 (Apr. 23, 1993) 39-45.
Totaro Imasaka et al, "Determination of Amino Acids by Capillary Zone Electrophoresis Based on Semiconductor Laser Fluorescence Detection" Analytical Chemistry, vol. 64, No. 7 (Apr. 1, 1992) 711-714.

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