Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-02-06
2007-02-06
Andres, Janet L. (Department: 1649)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100, C435S325000, C435S252300
Reexamination Certificate
active
10735256
ABSTRACT:
The invention relates generally to genes that encode proteins that inhibit axonal growth. The invention relates specifically to genes encoding NgR protein homologs in humans and mice. The invention also includes compositions and methods for modulating the expression and activity of Nogo and the NgR proteins. Specifically, the invention includes peptides, proteins and antibodies that block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, stroke or a demyelinating disease.
REFERENCES:
patent: 5250414 (1993-10-01), Schwab et al.
patent: 5684133 (1997-11-01), Schwab et al.
patent: 5858708 (1999-01-01), Bandman et al.
patent: 6025333 (2000-02-01), Schwab et al.
patent: 2002/0025554 (2002-02-01), Khodadoust
patent: 2003/0012704 (2003-07-01), Strittmatter et al.
patent: 2005/0221420 (2005-10-01), Barske et al.
patent: 2005/0271655 (2005-12-01), Lee et al.
patent: WO 98/06841 (1998-02-01), None
patent: WO 99/46281 (1999-09-01), None
patent: WO 99/66041 (1999-12-01), None
patent: WO 00/05364 (2000-02-01), None
patent: WO 00/31235 (2000-06-01), None
patent: WO 00/32221 (2000-06-01), None
patent: WO 00/37638 (2000-06-01), None
patent: WO 00/53756 (2000-09-01), None
patent: WO 00/53758 (2000-09-01), None
patent: WO 00/58473 (2000-10-01), None
patent: WO 00/70050 (2000-11-01), None
patent: WO 00/73452 (2000-12-01), None
patent: WO 01/09162 (2001-02-01), None
patent: WO 01/51520 (2001-07-01), None
patent: WO 03/018631 (2003-03-01), None
Gustafsson, J. A.. New insights in oestrogen receptor (ER) research-the ERb. Eur J Cancer. Sep. 2000;36 Suppl 4:S16.
Nykjaer et al. p75NTR—live or let die. Curr Opin Neurobiol. Feb. 2005; 15:49-57.
C.E. Bandtlow, et al., “NI-35/250/Nogo-A: A Neurite Growth Inhibitor Restricting Structural Plasticity and Regeneration of Nerve Fibers in the Adult Vertebrate CNS,”Glia, 29(2), pp. 175-181 (2000).
M.S. Chen, et al., “Nogo-A is a Myelin-Associated Neurite Outgrowth Inhibitor and an Antigen for Monoclonal Antibody IN-1,”Nature, 403(6768), pp. 434-439 (2000).
A.E. Fournier, et al., “Identification of a Receptor Mediating Nogo-66 Inhibition of Axonal Regeneration,”Nature, 409(6818), pp. 341-346 (2001).
T. GrandPre, et al., “Identification of the Nogo Inhibitor of Axon Regeneration as a Reticulon Protein,”Nature, 403(6768), pp. 439-444 (2000).
P. Hu, et al., “Homo Sapiens Chromosome 22q11 PAC Clone p215k21 Distal to DGCR Region,”EMBL Database Entry AC006549, Accession No. AC006549 (1999).
A.B. Huber, et al., “Nogo-A, a Potent Inhibitor of Neurite Outgrowth and Regeneration,”Biol. Chem., 381(5-6), pp. 407-419 (2000).
D. Merkler, et al., “Locomotor Recovery in Spinal Cord-Injured Rats Treated with an Antibody Neutralizing the Myelin-Associated Neurite Growth Inhibitor Nogo-A,”J. Neurosci., 21(10), pp. 3665-3673 (2001).
M. Oudega, et al., “Neutralizing Antibodies Against Neurite Growth Inhibitor NI-35/250 Do Not Promote Regeneration of Sensory Axons in the Adult Rat Spinal Cord,”Neuroscience, 100(4), pp. 873-883 (2000).
R. Prinjha, et al., “Inhibitor of Neurite Outgrowth in Humans,”Nature, 403(6768), pp. 383-384 (2000).
O. Raineteau, et al., “Sprouting and Regeneration After Pyramidotomy and Blockade of the Myelin-Associated Neurite Growth Inhibitors N1 35/250 in Adult Rats,”Eur. J. Neurosci., 11(4), pp. 1486-1490 (1999).
O. Raineteau, et al., “Functional Switch Between Motor Tracts in the Presence of the mAB IN-1 in the Adult Rat,”Proc. Natl. Acad. Sci. U.S.A., 98(12), pp. 6929-6934 (2001).
A.A. Spillmann, et al., “Identification and Characterization of a Bovine Neurite Growth Inhibitor (bNI-220),”J. Biol. Chem., 273(30), pp. 19283-19293 (1998).
M. Tatagiba, et al., “Regeneration of Injured Axons in the Adult Mammalian Central Nervous System,”Neurosurgery, 40(3), pp. 541-547 (1997).
M. Thallmair, et al., “Neurite Growth Inhibitors Restrict Plasticity and Functional Recovery Following Corticospinal Tract Lesions,”Nat. Neurosci., 1(2), pp. 124-131(1998).
W.J. Z'Graggen, et al., “Functional Recovery and Enhanced Corticofugal Plasticity After Unilateral Pyramidal Tract Lesion and Blockade of Myelin-Associated Neurite Growth Inhibitors in Adult Rats,”J. Neurosci., 18(12), pp. 4744-4757 (1998).
Pignot et al. “Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor,”J. Biochem. 85(3): 717-728 (2003).
Kobe and Kajava “The leucine-rich repeat as a protein recognition motif,”Curr. Opin. Structural Biol. 11(6):725-32 (2001).
Andrade et al. “Protein Repeats: Structures, Functions, and Evolution,”J. Structural Biol. 134: 117-131 (2001).
Skolnick et al. “From genes to protein structure and function: novel applications of computational approaches in the genomic era, ”Trends Biotech. 18:34-39 (2000).
Bork “Powers and Pitfalls in Sequence Analysis: The 70% Hurdle,”Genome Research10: 398-400 (2000).
Doerks et al. “Protein annotation: detective work for function prediction,”Trends Genet. 14: 248-250 (1998).
Smith et al. “The challenges of genome sequence annotation or ‘The devil is in the details,’”Nature Biotech. 15: 1222-1223 (1997).
Brenner “Errors in genome annotation,”Trends Genet. 15: 132-133 (1999).
Bork et al. “Go hunting in sequence databases but watch out for the traps,”Trends Genet. 12: 425-427 (1996).
Li et al. “The Genetic Defect in Two Well-Studied Cases of Bernard-Soulier Syndrome: A Point Mutation in the Fifth Leucine-Rich Repeat of Platelet Glycoprotein Ibα,”Blood86(10): 3805-3814 (1995).
Wang et al. “Localization of Nogo-A and Nogo-66 Receptor Proteins at Sites of Zxon-Myelin and Synpatic Contact.”J. Neurosci. 22 (13): 5505-5515 (2002).
Hunt et al. “Nogo Receptor mRNA Expression in Intact and Regenerating CNS Neurons,”Molec. Cellular Neurosci. 20(4): 537-552 (2002).
Wells “Additivity of Mutational Effects in Proteins,”Biochemistry29:8509-8517 (1990).
Ngo et al. “Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox,” inThe Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495 (1994).
Database EMBL, Accession No. AC013606, Birren, B., et al., 39 pages (Nov. 1999).
Database EMBL, Accession No. AC021768, Birren, B., et al., 74 pages (Jan. 2000).
Copy of Communication pursuant to Article 96(2) EPC for European Application No. 01 979 595.4, mailed May 17, 2005, European Patent Office, The Netherlands.
Domeniconi, M., et al., “Myelin-Associated Glycoprotein Interacts with the Nogo66 Receptor to Inhibit Neurite Outgrowth,”Neuron 35:283-290, Cell Press (Jul. 2002).
GrandPré, T., et al., “Nogo-66 receptor antagonist peptide promotes axonal regeneration,”Nature 417:547-551, Nature Publishing Group (May 2002).
International Search Report for International Application No. PCT/US2005/002535, European Patent Office, Netherlands, mailed Oct. 24, 2005.
Li, M., et al., “Effect of soluble Nogo reeceptor treatment on functional and histological outcome after spinal cord injury in the rat,” Biosis Database, Accession No. PREV200400194121, Abstract No. 80.22,Presented at the 33rd Annual Meeting of the Society of Neuroscience, New Orleans, LA (Nov. 8-12, 2003).
Li, W., et al., “A Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin,”J. Biol. Chem. 42:43780-43788, The American Society for Biochemistry and Molecular Biology, Inc. (Oct. 2004).
Li, W., et al., “Neutralization of NGR1 May Be Sufficient to Promote Rat DRG Neurite Outgrowth in the Presence of CNS Myeline,” SFN 2003 Abstract Viewer
Cate Richard L.
Sah Dinah W. Y.
Strittmatter Stephen M.
Andres Janet L.
Biogen Idec MA Inc.
Sterne Kessler Goldstein & Fox P.L.L.C.
Wang Chang-Yu
Yale University
LandOfFree
Nogo receptor homologs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nogo receptor homologs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nogo receptor homologs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3833072