Nod2 nucleic acids and proteins

Details Nod2 nucleic acids and proteins Nod2 nucleic acids and proteins

2006-06-13

2006-06-13

Wax, Robert A. (Department: 1653)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S252300, C435S254110, C435S320100, C536S023500

Reexamination Certificate

active

07060493

ABSTRACT:
The present invention relates to intracellular signalling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides isolated nucleotide sequence encoding Nod2, isolated Nod2 peptides, antibodies that specifically bind Nod2, methods for the detection of Nod2, and methods for screening compounds for the ability to alter Nod2 associated signal transduction.

REFERENCES:
patent: 2003/0190639 (2003-10-01), Hugot et al.
patent: 2005/0037378 (2005-02-01), Reed et al.
patent: WO 99/40102 (1999-08-01), None
patent: WO 99/64576 (1999-12-01), None
patent: WO 01/72822 (2001-10-01), None
patent: WO 01/90156 (2001-11-01), None
Maharies et al., “Sequence-Tagged Connectors; A Sequence Approach to Mapping and Scanning the Human Genome,” PNAS, vol. 96, No. 17 (Aug. 17, 1999), pp. 9739-9744.
Ogura et al., “A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease,” Nature vol. 411:603 [2001].
Hugot et al., “Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease,” Nature 411:6837 [2001].
Inohara et al., “The NOD: A signaling module that regulates apoptosis and host defense against pathogens,” Oncogene, 20:6473 [2001].
Ogura et al., “Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappa B,” J. Biol. Chem. 276:4812 [2001].
Database EMBL, Human NOD2 protein mRNA, Database accession No. AF178930.
Database EMBL, Jun. 7, 1999 “Sequencing of human chromosome 16,” Database accession No. AC007728.
Database EMBL May 18, 1999 “Use of BAC end sequences from library RPC1-11 for sequence-ready map building,” Database Accession No. AQ534686.
Hugot et al., “Mapping of a susceptibility locus for Crohn's disease on chromosome 16,” Nature 379:821 [1996].
Miceli-Richard et al., “CARD15 mutations in Blau syndrome,” Nature Genetics 29:19 [2001].
Inohara et al., “Nods: A family of cytosolic proteins that regulate the host response to pathogens,” Curr. Opin. Microbiol. 5:76 [2002].
Aderem and Ulevitch, Nature, 406:785-787 [2000].
Philpott et al., J. Immunol., 165:903-914 [2000].
Leister and Katagiri, Plant J., 22:345-354 [2000].
Hugot et al., Nature 379:821 [1996].
Chou et al., Cell, 94:171 [1998].
Kobe and Deisenhofer, Curr. Opin. Struct Biol., 5:409-416 [1995].
Zou et al., J. Bio. Chem. 274: 11549-11556 [1999].
Schwandner et al., J. Biol. Chem., 274: 17406-17409 [2000].
Inohara et al., J. Biol. Chem. 274: 14560-14568 [1999].
Li et al., Cell 91: 479-489 [1997].
Srinivamla et al., Mol. Cell 1: 949-957 [1998].
Hu et al., J. Bio. Chem. 273: 33489-34494 [1998].
Inohara et al., J. Biol. Chem. 273: 12296-12300 [1998].
McCarthy et al., J. Bio. Chem. 273, 16968-16975 [1998].
Parniske et al., Cell 91: 821-832 [1997].
Dixon et al., Proc. Natl. Acad. Sci. U. S. A. 97: 8807-8814 [2000].
Aliprantis et al., Science, 285:736-739 [1999].
Chow et al., J. Biol. Chem., 274:10689-10692 [2000].
Bertin et al., J. Biol. Chem., 274:12955-12958 (1999).
Thome et al., Curr. Biol., 8:885-888 [1998].
Inohara et al., J. biol. Chem., 275:27823-27831 [2000].
Shimada et al., Int. Immunol., 11:1357-1362 [1999].
Huang et al., PNAS, 94:12829-12832 [1997].
Medzhitov et al., Mol. Cell, 2:253-258 [1998].
Hsu et al., Immunity, 4:387-396 [1996].
Yamaoka et al., Cell 93: 1231-1240 [1998].
Hu et al., EMBO J. 18: 3586-3595 [1999].
Karin, J. Biol. Chem. 274: 27339-27342 [1999].
Hofmann et al., Trends Biochem. Sci. 22: 155-156 [1997].
MacCorkle et al., Proc. Nat. Acad. Sci. U. S. A. 95: 3655-3660 [1998].
Yang et al., Nature, 395:284-288 [1998].
Zou et al., Cell, 90:405-413 [1997].
Poltorak et al., Science, 282:2085 [1998].
Takeuchi et al., Immunity, 4:443 [1999].
Rietschel et al., Curr Top. Microbiol. Immunol., 216:39-81 [1997].
Cho et al., Inflammatory Bowel Diseases 3:186 [1997].
Cho et al., Proc. Natl. Acad. Sci. 95:7502 [1998].
Brant et al., Gastroenterology 115:1056 [1998].
Cho et al., Hum. Mol. Gent. 9:1425 [2000].
Cavanaugh et al., Ann. Hum. Gent. 62:291 [1998].
Tysk et al., Gut 29:990 [1988].

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