Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1981-06-03
1983-03-08
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
C12N 120
Patent
active
043761666
ABSTRACT:
New antibiotically active compounds having the basic structure of rifamycin S, namely 3-hydroxyrifamycin S (formula A: X=<C.dbd.O; R.sup.1 =OH; R.sup.2 =H), 3,31-dihydroxyrifamycin S (formula A: X=<C.dbd.O; R.sup.1 =R.sup.2 =OH) and 1-desoxy-1-oxarifamycin S (formula A: X=--O--; R.sup.1 =R.sup.2 =H) ##STR1## are formed by cultivating, under aerobic conditions, a strain of Nocardia mediterranei which is derived from Streptomyces mediterranei ATCC 13 685 as the parent strain and is characterized by the ability to produce at least one of the mentioned compounds. The recombinant strain Nocardia mediterranei DSM 1415 has proved suitable. The mentioned rifamycin S analogues have analogous antibiotic properties to this but have a wider range of action, especially against gram-negative bacteria.
REFERENCES:
Schupp et al. J. Bacteriology vol. 121 No. 1 pp. 128-136.
Helvetia Chimica Acta vol. 56, Fasc. 7 (1973) No. 239-240-2279.
Nuesch Jakob
Schupp Thomas
Traxler Peter
Almaula Prabodh I.
Ciba-Geigy Corporation
Glynn Michael W.
Gruenfeld Norbert
Tanenholtz Alvin E.
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