No synthase assay particles and method

Details No synthase assay particles and method No synthase assay particles and method

2007-09-04

2007-09-04

Tate, Christopher R. (Department: 1657)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Reexamination Certificate

active

10473240

ABSTRACT:
The invention relates to particles for use in a scintillation proximity assays. In particular, the invention relates to particles for use in a scintillation proximity assay for detecting nitric oxide synthase activity in a sample. The invention also relates to a method of measuring nitric oxide synthase activity in a sample using these particles in a scintillation proximity assay. The invention further relates to methods using these particles to detect the presence of modulators of nitric oxide synthase activity.

REFERENCES:
patent: 4278651 (1981-07-01), Hales
patent: 4568649 (1986-02-01), Bertoglio-Matte
patent: 6103379 (2000-08-01), Margel et al.
patent: 6150500 (2000-11-01), Salerno
patent: 0 556 0005 (1993-08-01), None
patent: 6299146 (1994-10-01), None
patent: WO91/08489 (1991-06-01), None
patent: WO96/11054 (1996-04-01), None
patent: WO99/09415 (1999-02-01), None
patent: WO00/69986 (2000-11-01), None
Bosworth, et al. “Scintillation Proximity Assay” Nature, MacMillan Journals Ltd., London, Great Britain vol. 341, Sep. 1989, pp. 167-168.
Cook, N. D. “Scintillation Proximity Assay: A Versatile High-Throughput Screening Technology” Drug Discovery Today, Elsevier Science Ltd., Great Britain vol. 1, No. 7, Jul. 1996, pp. 287-294.
“Methods in Enzymology” vol. 301, 1999, pp. 114-125.
Alderton, W., et al. “Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay” Biochemical Journal, vol. 332, No. 1, May 15, 1998, pp. 195-201.
Macarron, R., et al. “A homogenous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology” Analytical Biochemistry, vol. 284, No. 2, Sep. 10, 2000, pp. 183-190.
Woodbury, C. P., et al. “Methods of Screening Combinatorial Libraries Using Immobilized or Restrained Receptors” Journal of Chromatography B: Biomedical Sciences and Applications, Elsevier Science Publishers, NL, vol. 725, No. 1, Apr. 2, 1999, pp. 113-137.

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