No-carrier added radiohalogenated nucleosides

Details No-carrier added radiohalogenated nucleosides No-carrier added radiohalogenated nucleosides

1993-07-14

1995-06-06

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 2853, 436804, A61K 3170, A61K 5104, A61K10102, C07H 2102

Patent

active

054223458

ABSTRACT:
A composition comprising no-carrier-added 1-(B-D-arabinofuranosyl)-5-(E)-(2-halogenovinyl)uracil wherein the halogen is radioactive iodine or bromine. This composition can be used to diagnose or treat herpes viral infections.

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patent: 5248771 (1993-09-01), Dougan
S. L. Sacks, et al, Abstract 97, 28th Interscience Conference on Antimicrobial Agents and Chemotherapy (Oct. 1988)--"The Viral Thymidine Kinase (TK)-Dependent Uptake of 1-.beta.-D-arabinofuranosyl-E-5-(2-iodovinyl)uracil (IVaraU) etc." (p. 126.
Moren, et al., J. Labelled Compound and Radiopharmaceulicals, (1994) 35, 205-207.
Samuel et al. Int. J. Appl. Radiat. Isot. 35(11):1049-1052, 1984.
Vorbruggen et al. Appl. Radiat. Isot. 37(4):355-357, 1986.
Robbins et al. J. Med. Chem. 34:2275-2280, 1991.
Bleackley et al. Tetrahedron 32:2745-2747, 1976.

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