No-carrier-added (NCA) aryl (18E) fluorides via the nucleophilic

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

562446, 564360, 568433, 568437, C07C22942, C07C21308, C07C 4752

Patent

active

052547264

ABSTRACT:
A method for synthesizing no-carrier-added (NCA) aryl [.sup.18 F] fluoride substituted aromatic aldehyde compositions bearing an electron donating group is described. The method of the present invention includes the step of reacting aromatic nitro aldehydes having a suitably protected hydroxyl substitutent on an electron rich ring. The reaction is

REFERENCES:
Ding, et al. J. Flourine Chem. 48 (Jun. 8, 1990) 189-205.
Fowler et al., Annual Reports in Medicinal Chemistry, 24, 277, Allen (Ed.) cademic Press Inc., N.Y. (1989).
Jacobson, JAMA, 259, 2438 (1988).
Eisenhofer et al., J. Clin. Sci., 76, 171 (1989).
Rose et al., J. Clin. Invest., 76, 1740 (1985).
Fowler et al., J. Med. Chem., 17, 246 (1974).
Fowler et al., Radiopharmaceuticals, 196, Subramanian et al. (Eds.), The Society of Nuclear Medicine, Inc., N.Y. (1975).
Kilbourn, "Fluorine-18 Labeling of Radiopharmaceuticals", Nuclear Science Series, NAS-NS-3203, 1-149, National Academy Press, Wash., D.C. (1990).
Mislankar et al., J. Med. Chem., 31, 362 (1988).
Haka et al., J. Nucl. Med., 30, 767 (1989).
Wieland et al., J. Med. Chem., 33, 956 (1990).
Rosenspire et al., Nucl. Med. Biol., 16, 735 (1989).
Schwaiger et al., Circulation, 82, 457 (1990).
Kopin, Circulation, 82, 646, (Ed. Viewpoint) (1990).
Kirk et al., J. Med. Chem., 22, 1493 (1979).
Chiueh et al., J. Pharmacol. Exp. Ther., 225, 529 (1983).
Kirk, J. Org. Chem., 41, 2373 (1976).
Eisenhofer et al., J. Pharmacol. Exp. Ther., 248, 419 (1988).
Goldstein et al., Circulation, 82, 359 (1990).
Cacace et al., J. Label Cmpds. Radiopharm., 18, 1721 (1981).
Attina et al., J. Chem. Soc. Chem. Commun., 108, (1983).
Attina et al., J. Label Cmpds. Radiopharm., 20, 50 (1983).
Angelini et al., J. Fluorine Chem., 27, 177 (1985).
Shiue et al., J. Label. Cmpds. Radiopharm., 21, 533 (1984).
Lemaire et al., Int. J. Appl. Radiat. Isot., 38, 1033 (1987).
Haka et al., J. Label. Cmpds. Radiopharm., 27, 823 (1989).
Schuster et al., J. Org. Chem., 53, 5819 (1988).
Suryan et al., J. Am. Chem. Soc., 111, 1423 (1989).
Oguri et al., Chem. Pharm. Bull., 26, 803 (1978).
Antoni et al., Acta. Chem. Scan. B, 40, 152 (1986).
Carlson et al., J. Org. Chem., 36, 2319 (1971).
Gadekar et al., J. Hetero. Chem., 129 (1968).
Bhatt et al., Synthesis, 249, (1968).
Cole et al., Aust. J. Chem., 33, 675 (1980).
Matthews et al., Aust. J. Chem., 41, 1697 (1988).
Warasaka et al., Chem. Lett., 2073 (1987).
Ohta et al., Tetrahedron, 45, 5469 (1989).
Waldermann, Tetrahedron Lett., 30, 3057 (1989).
Wang et al., Tetrahedron Lett., 30, 1917 (1989).
Effenberger et al., Tetrahedron Lett., 31, 1249 (1990).
Maeda et al., Appl. Radiat. Isot., 41, 463 (1990).
Levin et al., J. Biol. Chem., 235, 2080 (1960).
Goldstein et al., J. Biol. Chem., 237, 1898 (1962).
Salomaa et al., Acta. Chem. Scand., 15, 871 (1961).
Matthaei et al., Naunyn-Schmiedeberg's Arch. Pharmacol., 337, 621 (1988).
Johnstone et al., Tetrahedron, 35, 2169 (1979).
Dewey et al., Synapse, 5, 213 (1990).
Plenevaux et al. Appl. Radiat. Isot. 42(2), 121-7, 1991.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

No-carrier-added (NCA) aryl (18E) fluorides via the nucleophilic does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with No-carrier-added (NCA) aryl (18E) fluorides via the nucleophilic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and No-carrier-added (NCA) aryl (18E) fluorides via the nucleophilic will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1353111

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.