No-carrier-added (18F)-N-methylspiroperidol

Details No-carrier-added (18F)-N-methylspiroperidol No-carrier-added (18F)-N-methylspiroperidol

1985-10-04

1993-07-06

Stoll, Robert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

546 20, A61K 4300

Patent

active

H00012092

ABSTRACT:
There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.

REFERENCES:
patent: 2348231 (1940-06-01), Strain et al.
patent: 3155670 (1964-11-01), Janssen
patent: 3981769 (1976-09-01), Winchell et al.
patent: 4197288 (1980-04-01), Snyder
patent: 4279887 (1981-07-01), Baldwin et al.
patent: 4280993 (1981-07-01), Braestrup et al.
patent: 4292321 (1981-09-01), Pattison
patent: 4473544 (1984-09-01), Machulla et al.
patent: 4656280 (1987-04-01), Garlick
Tewson et al, Brain Research, 192, 291-295 (1980).
Tewson et al, J. Labelled Compounds and Radiopharmaceuticals, XVIII, Nos. 1-2, 21-23, 102-103, (1980).
Wagner et al, Science, 221, 1264-1266 (1983).
Burns et al, J. Nuclear Medicine, 25(11), 1222-1227 (1984).

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