Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1986-04-17
1989-10-17
Maples, John S.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424 9, 564511, A61K 4902, C07C 8714
Patent
active
048746002
ABSTRACT:
The invention relates to a new radiolabeled imaging agent, no-carrier-added [1-.sup.11 C]putrescine, and to the use of this very pure material as a radiotracer with positron emission tomography for imaging brain tumors. The invention further relates to the synthesis of no-carrier-added [1-.sup.11 C]putrescine based on the Michael addition of potassium .sup.11 C-labeled cyanide to acrylonitrile followed by reduction of the .sup.11 C-labeled dinitrile. The new method is rapid and efficient and provides radiotracer with a specific activity greater than 1.4 curies per millimol and in a purity greater than 95%.
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McPherson et al., Syn. and Biodistribution, of No-Carrier-Added [1-.sup.11 C] Putrescine., J. Nucl. Med., 26, Oct. 1985, 1186-1189.
Fowler Joanna S.
McPherson Daniel W.
Wolf Alfred P.
Bogosian Margaret C.
Gottlieb Paul A.
Hightower Judson R.
Maples John S.
The United States of America as represented by the United States
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