NMR System for determining relationship between work output and

Details NMR System for determining relationship between work output and NMR System for determining relationship between work output and

1982-08-19

1984-04-10

Howell, Kyle L.

Surgery

Truss

Pad

A61B 505

Patent

active

044415028

ABSTRACT:
A NMR apparatus for determining the relationship between work output of an exercising body member and the steady-state capability of oxidative phosphorylation of the muscle tissue as measured by the PCr/P.sub.i ratio in the tissue. The apparatus includes the large hollow magnet of the NMR system, with a radio frequency probe mounted therein, arranged to underlie a human limb, such as an arm, inserted in the magnet from one end. Adjacent to the opposite end a Cybex ergometer is mounted. A hand lever is pivotally mounted in the magnet and is connected by a link bar to the drive arm of the ergometer. The subject inserts his arm in the magnet and grasps the hand lever, performing controlled work strokes at uniformly spaced short intervals over a selected length of time, such as 10 minutes, observing the output trace of the ergometer and maintaining a constant work output intensity with each stroke. The NMR apparatus provides curves of the NMR response at 24.3 MHz and a magnetic field of 20 kg, showing the intensities of the phosphorus-containing components of the muscle tissue, including PCr and P.sub.i. This enables accurate measurement and monitoring of the work output from the muscle simultaneously with the generation of the phosphorus NMR response curves. A curve may be plotted showing PCr/P.sub.i versus time, which affords criteria of muscle performance. Another useful curve may be plotted showing muscle unit volume work rate in terms of joules/sec versus P.sub.i /PCr, also capable of detecting biochemical abnormality, muscle dystrophy or vascular disease.

REFERENCES:
patent: 4354499 (1982-10-01), Damadian
patent: 4413233 (1983-11-01), Fossel et al.
Mansfield, P. et al., "NMR Imaging in Bio-Medicine", Academic Press, New York & London, 1982, pp. 238-242.

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