NMR imaging using paramagnetic chelates having hydroxyalkyl-subs

Details NMR imaging using paramagnetic chelates having hydroxyalkyl-subs NMR imaging using paramagnetic chelates having hydroxyalkyl-subs

1990-04-13

1994-05-31

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, 1286534, 514492, 514836, 534 16, 556 50, 556 63, 556107, 556117, 556134, 556148, A61B 5055, C07F 500

Patent

active

053167562

ABSTRACT:
Compounds of the general formula I: ##STR1## R.sup.1 signifies a COOX group or the group ##STR2## R.sup.2 and R.sup.3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarbon radical, a phenyl or benzyl group or either R.sup.2 or R.sup.3 signifies the group ##STR3## or R.sup.2 or R.sup.3 together signify a trimethylene or tetramethylene radical, R.sup.4 represents a straight- or branched-chain mono- or poly-hydroxyalkyl radical, R.sup.5 represents a hydrocarbon atom, a lower straight- or branched-chain, optionally mono- or poly-hydroxylated, hydrocarbon radical, Q signifies an oxygen or sulfur atom or the group ##STR4## wherein j signifies the numbers 1 to 4 and R.sup.x signifies a hydrogen atom, a lower alkoxy group with 1 to 4 carbon atoms, a COOX group, or if j>1, also the group ##STR5## wherein k and m are the same or different and represent the numbers 0 or 2, l signifies the numbers 1 or 2 and n and w are the same or different and signify the numbers 0 or 1,

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