NMR contrast agents

Details NMR contrast agents NMR contrast agents

1992-07-13

1995-03-28

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

514 53, 514 57, 514 59, 514557, A61K 4900, A61K 31715, A61K 3119

Patent

active

054014913

ABSTRACT:
An agent for modifying H.sub.2 O relaxation times in NMR diagnosis comprises a polysaccharide having chemically linked to it an organic complexant to which is complexed a paramagnetic metal ion. Polysaccharides include cellulose, starch, sepharose and dextran. Organic complexants include EDTA, DTPA and aminoethyl diphosphonate. A preferred metal ion is Gadolinium (III). The agents can be administered orally or parenterally.

REFERENCES:
patent: 4385046 (1983-05-01), Milbrath et al.
patent: 4423158 (1983-01-01), Porath
patent: 4615879 (1986-10-01), Runge et al.
patent: 4647447 (1987-03-01), Gries et al.
patent: 4719098 (1988-01-01), Weinmann et al.

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