NMR contrast agents

Details NMR contrast agents NMR contrast agents

1985-05-30

1987-12-22

Sneed, Helen M. S.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

556 50, 556 63, 556148, 534 16, A61K 4900, G01N 3100, G01N 3348

Patent

active

047146079

ABSTRACT:
There are provided NMR contrast agents comprising water-soluble paramagnetic metal chelates, preferably of Cr(III), Fe(III) or Gd(III), wherein the chelating entity is an anilide group containing organic moiety, preferably a compound of formula I ##STR1## wherein R.sup.1 to R.sup.5 may represent hydrogen or halogen atoms, optionally halogenated alkyl or alkoxy groups or carboxyl groups. The agents are especially suitable for use in NMR imaging of the hepatobiliary system.

REFERENCES:
patent: 3150160 (1964-09-01), Dexter
patent: 3158635 (1964-11-01), Kezerian et al.
patent: 3687992 (1972-08-01), Feiler et al.
patent: 4017596 (1977-04-01), Loberg et al.
patent: 4046793 (1977-09-01), Baccini et al.
patent: 4308249 (1981-12-01), Frank et al.
patent: 4316883 (1982-02-01), Schriver
patent: 4318898 (1982-03-01), Molter et al.
patent: 4418208 (1983-11-01), Nunn et al.
patent: 4472509 (1984-09-01), Gansow et al.
Martell & Calvin, Chemistry of the Metal Chelate Compounds, Prentice-Hall, Inc. N.Y., pp. 39 to 46, 475-481, 510 and 527-541, (1952).
Runge et al., AJR, vol. 141, pp. 1209-1215 (1983).

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